Secondary pseudohypoaldosteronism: a 15-year experience and a literature review.

Autor: Moreno Sánchez A; Pediatric Nephrology Unit, Department of Pediatrics, Hospital Universitario Miguel Servet, P.º de Isabel La Católica, 1-3, Zaragoza, Spain. ameliamorenosanchez111@gmail.com., García Atarés Á; Pediatric Nephrology Unit, Department of Pediatrics, Hospital Universitario Miguel Servet, P.º de Isabel La Católica, 1-3, Zaragoza, Spain., Molina Herranz D; Pediatric Nephrology Unit, Department of Pediatrics, Hospital Universitario Miguel Servet, P.º de Isabel La Católica, 1-3, Zaragoza, Spain., Antoñanzas Torres I; Pediatric Nephrology Unit, Department of Pediatrics, Hospital Universitario Miguel Servet, P.º de Isabel La Católica, 1-3, Zaragoza, Spain., Romero Salas Y; Pediatric Nephrology Unit, Department of Pediatrics, Hospital Universitario Miguel Servet, P.º de Isabel La Católica, 1-3, Zaragoza, Spain., Ruiz Del Olmo Izuzquiza JI; Pediatric Nephrology Unit, Department of Pediatrics, Hospital Universitario Miguel Servet, P.º de Isabel La Católica, 1-3, Zaragoza, Spain.
Jazyk: angličtina
Zdroj: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2024 Nov; Vol. 39 (11), pp. 3233-3239. Date of Electronic Publication: 2024 Jun 28.
DOI: 10.1007/s00467-024-06428-z
Abstrakt: Background: Secondary pseudohypoaldosteronism (S-PHA) is a rare condition resulting from renal tubular resistance to aldosterone in children with urinary tract infection (UTI) and/or nephrourological malformations. It is characterized by nonspecific symptoms but with the potential for life-threatening complications. We aim to evaluate the clinical manifestations, diagnostic approach, and therapeutic interventions in children with S-PHA, along with a review of recent publications.
Methods: A retrospective observational descriptive study was conducted on S-PHA cases diagnosed over the last 15 years at a tertiary pediatric nephrology unit. The literature for the last 10 years was reviewed.
Results: Twelve patients (10 males, 6 days to 6 months) were identified. Weight loss was the main reason for consultation (50%). Ninety-two percent of patients had an underlying nephrourological pathology and 62% concomitant confirmed UTI. Seven out of 12 children were admitted to the PICU. A subsequent extrapontine myelinolysis was observed in one patient as neurological sequelae. Twenty-one articles related to S-PHA have been identified on PubMed and Embase.
Conclusions: S-PHA should be considered in infants under 6 months of age with UTI and/or CAKUT. Obstructive anomalies and vesicoureteral reflux can be found, affecting both unilateral and bilateral systems. Early medical and surgical interventions are crucial and require close monitoring to avoid iatrogenic complications.
(© 2024. The Author(s), under exclusive licence to International Pediatric Nephrology Association.)
Databáze: MEDLINE
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