Predictive model of IVF outcomes for polycystic ovarian morphology and polycystic ovary syndrome in GnRH antagonist protocol using AMH-MoM and ovarian sensitivity index.

Autor: Ko YR; Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, South Korea., Yu EJ; Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, South Korea.; Seoul Infertility and Genetics Clinic: CHA Fertility Center, Seoul, South Korea., Park JE; Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, South Korea., Park JK; Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, South Korea., Eum JH; Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, South Korea., Kim TH; Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, South Korea., Lee WS; Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, South Korea., Lee HJ; Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, South Korea.
Jazyk: angličtina
Zdroj: The journal of obstetrics and gynaecology research [J Obstet Gynaecol Res] 2024 Sep; Vol. 50 (9), pp. 1667-1674. Date of Electronic Publication: 2024 Jun 27.
DOI: 10.1111/jog.16009
Abstrakt: Aim: To evaluate the relationship between AMH and ovarian response to controlled ovarian hyperstimulation in women with PCOM and PCOS.
Methods: A retrospective study was conducted on 559 patients who underwent the IVF-ET cycle between January 2018 and December 2022 at Gangnam Cha Hospital. Patients were divided into 3 groups matched for age and BMI: the PCOS group (n = 54), based on the new 2023 PCOS guideline; the PCOM group (n = 53); and the control group (n = 452) with normal ovaries. Serum AMH levels were converted to multiples of the median (MoM) for each corresponding age. The ovarian sensitivity index (OSI) was calculated as the number of retrieved oocytes divided by the total dose of recombinant FSH administered (per 1000 IU).
Results: There were significant differences in AMH-MoM value among women with PCOS [2.7 ± 1.3 (95% CI 2.3-3.0)], those with PCOM [2.0 ± 1.0 (95% CI 1.7-2.3)], and controls [0.8 ± 0.7 (95% CI 0.8-0.9)] (p < 0.001). The abortion rates in the normoovulatory, PCOM, and PCOS groups were 18.2%, 21.1%, and 25.0%, respectively. OSI and live birth rate were positively correlated with the AMH-MoM value in normoovulatory women (r = 0.389, p < 0.05, r = 0.122, p < 0.05), while no such correlation was observed in women with PCOM and PCOS.
Conclusions: Ovarian response and live birth rate are possibly correlated with the AMH-MoM value in normoovulatory women, but not in women with PCOM and PCOS.
(© 2024 The Author(s). Journal of Obstetrics and Gynaecology Research published by John Wiley & Sons Australia, Ltd on behalf of Japan Society of Obstetrics and Gynecology.)
Databáze: MEDLINE
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