NOSH-aspirin (NBS-1120) inhibits estrogen receptor negative breast cancer in vitro and i n vivo by modulating redox-sensitive signaling pathways.
Autor: | Chattopadhyay M; Molecular, Cellular and Biomedical Sciences, City University of New York School of Medicine, United States., Nath N; Biological and Chemical Sciences, New York Institute of Technology, United States., Kodela R; Molecular, Cellular and Biomedical Sciences, City University of New York School of Medicine, United States., Metkar S; Molecular, Cellular and Biomedical Sciences, City University of New York School of Medicine, United States., Soyemi SA; Molecular, Cellular and Biomedical Sciences, City University of New York School of Medicine, United States., Kashfi K; Molecular, Cellular and Biomedical Sciences, City University of New York School of Medicine, United States kkashfi@med.cuny.edu. |
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Jazyk: | angličtina |
Zdroj: | The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2024 Jun 27. Date of Electronic Publication: 2024 Jun 27. |
DOI: | 10.1124/jpet.124.002240 |
Abstrakt: | Estrogen receptor (ER)-negative breast cancers are known to be aggressive and unresponsive to anti-estrogen therapy, and triple negative breast cancers are associated with poor prognosis and metastasis. Thus, new targeted therapies are needed. FOXM1 is abundantly expressed in human cancers and implicated in protecting tumor cells from oxidative stress by reducing the levels of intracellular reactive oxygen species (ROS). Aspirin, a prototypical anti-cancer agent with deleterious side effects, has been modified to release nitric oxide and hydrogen sulfide, called NOSH-aspirin (NOSH-ASA), generating a 'safer' class of new anti-inflammatory agents. We evaluated NOSH-ASA against (ER)-negative breast cancer using cell lines and a xenograft mouse model. NOSH-ASA strongly inhibited growth of MDA-MB-231 and SKBR3 breast cancer cells with low IC (Copyright © 2024 American Society for Pharmacology and Experimental Therapeutics.) |
Databáze: | MEDLINE |
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