Review: the spectrum of antimicrobial resistance in bacteria isolated from wounds of patients with epidermolysis bullosa.

Autor: Jayawardena NS; Department of Dermatology, Sydney Children's Hospital, Randwick, Australia.; Faculty of Medicine and Health, University of New South Wales, Kensington, Australia., Wargon O; Department of Dermatology, Sydney Children's Hospital, Randwick, Australia.; Faculty of Medicine and Health, University of New South Wales, Kensington, Australia., Tatian AH; Department of Dermatology, Sydney Children's Hospital, Randwick, Australia.; Faculty of Medicine and Health, University of New South Wales, Kensington, Australia.
Jazyk: angličtina
Zdroj: The Journal of dermatological treatment [J Dermatolog Treat] 2024 Dec; Vol. 35 (1), pp. 2370424. Date of Electronic Publication: 2024 Jun 27.
DOI: 10.1080/09546634.2024.2370424
Abstrakt: Purpose: Cutaneous infection in epidermolysis bullosa (EB) can cause significant morbidity, mortality, and dangerous sequelae. This review article aims to delve into the known epidemiology of EB, highlight the disease's primary causative agents and their antimicrobial resistance spectrum. Materials and methods: A thorough literature search was conducted using Medline, EMBASE, JBI and PubMed to gather data on the microbial landscape of EB wounds. The focus was on identifying the most common bacteria associated with EB infections and assessing their antimicrobial resistance profiles. Results: The analysis revealed that Staphylococcus aureus is the most frequently identified bacterium in EB wounds, with a notable prevalence of methicillin-resistant strains (MRSA). Specific studies on mupirocin resistance further indicated rising rates of mupirocin-resistant Staphylococcus aureus , with one study reporting rates as high as 16.07%. Additionally, high resistance to other antibiotics, such as levofloxacin and trimethoprim/sulfamethoxazole, was observed in MRSA isolates. Conclusions: The findings highlight the critical need for regular resistance surveillance and the prudent use of mupirocin to manage infections effectively in EB. The multi-drug resistant nature of pathogens in EB presents a significant challenge in treatment, highlighting the importance of antimicrobial stewardship. Ultimately, given the sparse literature and the rarity of large-scale studies, further longitudinal research on the antimicrobial resistance profile of bacteria isolated from EB wounds is essential.
Databáze: MEDLINE
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