Printable Poly(3,4-ethylenedioxythiophene)-Based Conductive Patches for Cardiac Tissue Remodeling.

Autor:	Luque GC; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramón 194, Donostia-San Sebastián 20014, Spain.; Instituto de Desarrollo Tecnológico para la Industria Química (INTEC) CONICET, Güemes 3450, Santa Fe 3000, Argentina., Picchio ML; POLYMAT University of the Basque Country UPV/EHU, Joxe Mari Korta Center, Avda. Tolosa 72, Donostia-San Sebastián 20018, Spain., Daou B; Instituto de Desarrollo Tecnológico para la Industria Química (INTEC) CONICET, Güemes 3450, Santa Fe 3000, Argentina.; IIS Biodonostia, Neurosciences Area, Group of Neuromuscular Diseases, Paseo Dr. Begiristain s/n, San Sebastian 20014, Spain., Lasa-Fernandez H; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramón 194, Donostia-San Sebastián 20014, Spain., Criado-Gonzalez M; POLYMAT University of the Basque Country UPV/EHU, Joxe Mari Korta Center, Avda. Tolosa 72, Donostia-San Sebastián 20018, Spain., Querejeta R; Servicio de Cardiología, Hospital Universitario Donostia, San Sebastián, Gipuzkoa 20014, España., Filgueiras-Ramas D; Centro Nacional de Investigaciones Cardiovasculares; CIBER de Enfermedades Cardiovasculares, Hospital Clínico Universitario San Carlos, Madrid 28029, Spain., Prato M; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramón 194, Donostia-San Sebastián 20014, Spain.; Department of Chemical and Pharmaceutical Sciences, INSTM Unit of Trieste, University of Trieste, Via L. Giorgieri 1, Trieste 34127, Italy.; Ikerbasque, Basque Foundation for Science, Bilbao 48013, Spain., Mecerreyes D; POLYMAT University of the Basque Country UPV/EHU, Joxe Mari Korta Center, Avda. Tolosa 72, Donostia-San Sebastián 20018, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao 48013, Spain., Ruiz-Cabello J; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramón 194, Donostia-San Sebastián 20014, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao 48013, Spain.; Ciber Enfermedades Respiratorias (Ciberes), Madrid 28029, Spain.; NMR and Imaging in Biomedicine Group, Department of Chemistry in Pharmaceutical Sciences, Pharmacy School, University Complutense Madrid, Madrid 28040, Spain., Alegret N; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramón 194, Donostia-San Sebastián 20014, Spain.; POLYMAT University of the Basque Country UPV/EHU, Joxe Mari Korta Center, Avda. Tolosa 72, Donostia-San Sebastián 20018, Spain.; IIS Biodonostia, Neurosciences Area, Group of Neuromuscular Diseases, Paseo Dr. Begiristain s/n, San Sebastian 20014, Spain.
Jazyk:	angličtina
Zdroj:	ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2024 Jul 10; Vol. 16 (27), pp. 34467-34479. Date of Electronic Publication: 2024 Jun 27.
DOI:	10.1021/acsami.4c03784
Abstrakt:	Myocardial cardiopathy is one of the highest disease burdens worldwide. The damaged myocardium has little intrinsic repair ability, and as a result, the distorted muscle loses strength for contraction, producing arrhythmias and fainting, and entails a high risk of sudden death. Permanent implantable conductive hydrogels that can restore contraction strength and conductivity appear to be promising candidates for myocardium functional recovery. In this work, we present a printable cardiac hydrogel that can exert functional effects on networks of cardiac myocytes. The hydrogel matrix was designed from poly(vinyl alcohol) (PVA) dynamically cross-linked with gallic acid (GA) and the conductive polymer poly(3,4-ethylenedioxythiophene) (PEDOT). The resulting patches exhibited excellent electrical conductivity, elasticity, and mechanical and contractile strengths, which are critical parameters for reinforcing weakened cardiac contraction and impulse propagation. Furthermore, the PVA-GA/PEDOT blend is suitable for direct ink writing via a melting extrusion. As a proof of concept, we have proven the efficiency of the patches in propagating the electrical signal in adult mouse cardiomyocytes through in vitro recordings of intracellular Ca 2+ transients during cell stimulation. Finally, the patches were implanted in healthy mouse hearts to demonstrate their accommodation and biocompatibility. Magnetic resonance imaging revealed that the implants did not affect the essential functional parameters after 2 weeks, thus showing great potential for treating cardiomyopathies.
Databáze:	MEDLINE
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