Lethality associated with snake venom exposure can be predicted by temperature drop in Swiss mice.

Autor: De Jesus R; Bioterio, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), City of Knowledge, Panama City, 0843-01103, Panama. Electronic address: rdejesus@indicasat.org.pa., Britton GB; Centro de Neurociencias, INDICASAT AIP, City of Knowledge, Panama City, 0843-01103, Panama; Sistema Nacional de Investigación (SNI), SENACYT, Panama City, 0816-02852, Panama. Electronic address: gbritton@indicasat.org.pa., Herrera L; Bioterio, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), City of Knowledge, Panama City, 0843-01103, Panama. Electronic address: lmherrera@indicasat.org.pa., Madrid A; Bioterio, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), City of Knowledge, Panama City, 0843-01103, Panama. Electronic address: amadrid@indicasat.org.pa., Lleonart R; Sistema Nacional de Investigación (SNI), SENACYT, Panama City, 0816-02852, Panama; Centro de Biología Celular y Molecular de Enfermedades, INDICASAT AIP, City of Knowledge, Panama City, 0843-01103, Panama. Electronic address: rlleonart@indicasat.org.pa., Fernández PL; Sistema Nacional de Investigación (SNI), SENACYT, Panama City, 0816-02852, Panama; Centro de Biología Celular y Molecular de Enfermedades, INDICASAT AIP, City of Knowledge, Panama City, 0843-01103, Panama. Electronic address: pllanes@indicasat.org.pa.
Jazyk: angličtina
Zdroj: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2024 Aug 28; Vol. 247, pp. 107831. Date of Electronic Publication: 2024 Jun 25.
DOI: 10.1016/j.toxicon.2024.107831
Abstrakt: Establishing humane endpoints to minimize animal suffering in studies on snake venom toxicity and antivenom potency tests is crucial. Our findings reveal that Swiss mice exhibit early temperature drop following exposure to different snake venoms and combinations of venoms and antivenoms, predicting later mortality. Evaluating temperature we can identify within 3 h post-inoculation, the animals that will not survive in a period of 48 h. Implementing temperature as a criterion would significantly reduce animal suffering in these studies without compromising the outcomes.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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