Anti-cancer property and DNA binding interaction of first row transition metal complexes: A decade update.

Autor: Dasmahapatra U; Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632014, India., Maiti B; Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632014, India. Electronic address: barnalimaiti.m@gmail.com., Alam MM; Department of Chemistry, College of Science, King Khalid University, P.O. Box 9004, Abha, 61413, Saudi Arabia., Chanda K; Department of Chemistry, Rabindranath Tagore University, Hojai, Assam, 782435, India. Electronic address: chandakaushik1@gmail.com.
Jazyk: angličtina
Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2024 Sep 05; Vol. 275, pp. 116603. Date of Electronic Publication: 2024 Jun 19.
DOI: 10.1016/j.ejmech.2024.116603
Abstrakt: Metal ions carry out a wide variety of functions, including acid-base/redox catalysis, structural functions, signaling, and electron transport. Understanding the interactions of transition metal complexes with biomacromolecules is essential for biology, medicinal chemistry, and the production of synthetic metalloenzymes. After the coincidental discovery of cisplatin, importance of the metal complexes in biochemistry became a top priority for inquiry. In this review, a decade update on various synthetic strategies to first row transition metal complex and their interaction with DNA through non-covalent binding are explored. Moreover, this effort provides an excellent analysis on the efficacy of theoretical and practical approaches to the systematic generation of new non-platinum based metallodrugs for anti-cancer therapeutics.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Kaushik Chanda reports financial support was provided by Rabindranath Tagore University. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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Databáze: MEDLINE
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