Genetic ancestry is related to potential sources of breast cancer health disparities among Colombian women.
Autor: | Rey-Vargas L; National Cancer Institute, Cancer Biology Research Group, Bogotá, D.C, Colombia.; Doctoral Program in Biological Sciences, Pontificia Universidad Javeriana, Bogotá, D.C, Colombia., Bejarano-Rivera LM; National Cancer Institute, Cancer Biology Research Group, Bogotá, D.C, Colombia., Serrano-Gómez SJ; National Cancer Institute, Cancer Biology Research Group, Bogotá, D.C, Colombia.; National Cancer Institute, Research Support and Follow-Up Group, Bogotá, D.C, Colombia. |
---|---|
Jazyk: | angličtina |
Zdroj: | PloS one [PLoS One] 2024 Jun 27; Vol. 19 (6), pp. e0306037. Date of Electronic Publication: 2024 Jun 27 (Print Publication: 2024). |
DOI: | 10.1371/journal.pone.0306037 |
Abstrakt: | Breast cancer health disparities are linked to clinical-pathological determinants, socioeconomic inequities, and biological factors such as genetic ancestry. These factors collectively interact in complex ways, influencing disease behavior, especially among highly admixed populations like Colombians. In this study, we assessed contributing factors to breast cancer health disparities according to genetic ancestry in Colombian patients from a national cancer reference center. We collected non-tumoral paraffin embedded (FFPE) blocks from 361 women diagnosed with breast cancer at the National Cancer Institute (NCI) to estimate genetic ancestry using a 106-ancestry informative marker (AIM) panel. Differences in European, Indigenous American (IA) and African ancestry fractions were analyzed according to potential sources of breast cancer health disparities, like etiology, tumor-biology, treatment administration, and socioeconomic-related factors using a Kruskal-Wallis test. Our analysis revealed a significantly higher IA ancestry among overweight patients with larger tumors and those covered by a subsidized health insurance. Conversely, we found a significantly higher European ancestry among patients with smaller tumors, residing in middle-income households, and affiliated to the contributory health regime, whereas a higher median of African ancestry was observed among patients with either a clinical, pathological, or stable response to neoadjuvant treatment. Altogether, our results suggest that the genetic legacy among Colombian patients, measured as genetic ancestry fractions, may be reflected in many of the clinical-pathological variables and socioeconomic factors that end up contributing to health disparities for this disease. Competing Interests: The authors have declared that no competing interests exist. (Copyright: © 2024 Rey-Vargas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.) |
Databáze: | MEDLINE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |