Is the rise in childhood obesity rates leading to an increase in hospitalizations due to dengue?

Autor: Jeewandara C; Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura, Nugegoda, Sri Lanka., Karunananda MV; Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura, Nugegoda, Sri Lanka., Fernando S; Ministry of Health, Colombo, Sri Lanka., Danasekara S; Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura, Nugegoda, Sri Lanka., Jayakody G; Ministry of Health, Colombo, Sri Lanka., Arulkumaran S; Ministry of Health, Colombo, Sri Lanka., Samaraweera NY; Ministry of Health, Colombo, Sri Lanka., Kumarawansha S; Ministry of Health, Colombo, Sri Lanka., Sivaganesh S; Ministry of Health, Colombo, Sri Lanka., Amarasinghe PG; Ministry of Health, Colombo, Sri Lanka., Jayasinghe C; Ministry of Health, Colombo, Sri Lanka., Wijesekara D; Ministry of Health, Colombo, Sri Lanka., Marasinghe MB; Ministry of Health, Colombo, Sri Lanka., Mambulage U; Ministry of Health, Colombo, Sri Lanka., Wijayatilake H; Ministry of Health, Colombo, Sri Lanka., Senevirathne K; Ministry of Health, Colombo, Sri Lanka., Bandara ADP; Ministry of Health, Colombo, Sri Lanka., Gallage CP; Ministry of Health, Colombo, Sri Lanka., Colambage NR; Ministry of Health, Colombo, Sri Lanka., Udayasiri AAT; Ministry of Health, Colombo, Sri Lanka., Lokumarambage T; Ministry of Health, Colombo, Sri Lanka., Upasena Y; Ministry of Health, Colombo, Sri Lanka., Weerasooriya WPKP; Ministry of Health, Colombo, Sri Lanka., Ogg GS; MRC Translational Immune Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom., Malavige GN; Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.; MRC Translational Immune Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2024 Jun 27; Vol. 18 (6), pp. e0012248. Date of Electronic Publication: 2024 Jun 27 (Print Publication: 2024).
DOI: 10.1371/journal.pntd.0012248
Abstrakt: Background: Obesity and diabetes are known risk factors for severe dengue. Therefore, we sought to investigate the association of obesity with increased risk of hospitalization, as there is limited information.
Methods and Findings: Children aged 10 to 18 years (n = 4782), were recruited from 9 districts in Sri Lanka using a stratified multi-stage cluster sampling method. Details of previous admissions to hospital due to dengue and anthropometric measurements were recorded and seropositivity rates for dengue were assessed. The body mass index (BMI) centile in children aged 10 to 18, was derived by plotting the values on the WHO BMI-for-age growth charts, to acquire the percentile ranking.
Results: Although the dengue seropositivity rates were similar in children of the different BMI centiles, 12/66 (18.2%) seropositive children with a BMI centile >97th, had been hospitalized for dengue, compared to 103/1086 (9.48%) of children with a BMI centile of <97th. The logistic regression model suggested that BMI centiles 50th to 85th (OR = 1.06, 95% CI, 1.00 to 1.11, p = 0.048) and BMI centile of >97th (OR 2.33, 95% CI, 1.47 to 3.67, p = 0.0003) was significantly associated with hospitalization when compared to children in other BMI categories.
Conclusions: Obesity appears to be associated with an increased risk of hospitalization in dengue, which should be further investigated in longitudinal prospective studies. With the increase in obesity in many countries, it would be important to create awareness regarding obesity and risk of severe disease and hospitalization in dengue.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Jeewandara et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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