| Autor: |
Harriswangler C; Universidade da Coruña, Centro Interdisciplinar de Química e Bioloxía (CICA) and Departamento de Química, Facultade de Ciencias, A Coruña 15071, Galicia, Spain., Omweri JM; Department of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama 35205, United States.; Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States., Saini S; Department of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama 35205, United States.; Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States., Valencia L; Departamento de Química Inorgánica, Facultad de Ciencias, Universidade de Vigo, As Lagoas, Marcosende 36310, Pontevedra, Spain., Esteban-Gómez D; Universidade da Coruña, Centro Interdisciplinar de Química e Bioloxía (CICA) and Departamento de Química, Facultade de Ciencias, A Coruña 15071, Galicia, Spain., Ranga M; Bracco Imaging SpA, CRB Trieste, AREA Science Park, ed. Q─S.S. 14 Km 163,5, 34149 Basovizza, TS, Italy., Guidolin N; Bracco Imaging SpA, CRB Trieste, AREA Science Park, ed. Q─S.S. 14 Km 163,5, 34149 Basovizza, TS, Italy., Baranyai Z; Bracco Imaging SpA, CRB Trieste, AREA Science Park, ed. Q─S.S. 14 Km 163,5, 34149 Basovizza, TS, Italy., Lapi SE; Department of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama 35205, United States.; Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States., Platas-Iglesias C; Universidade da Coruña, Centro Interdisciplinar de Química e Bioloxía (CICA) and Departamento de Química, Facultade de Ciencias, A Coruña 15071, Galicia, Spain. |
| Abstrakt: |
We report the [ nat Mn/ 52 Mn]Mn(II) complexes of the macrocyclic chelators PYAN [3,6,10,13-tetraaza-1,8(2,6)-dipyridinacyclotetradecaphane] and CHXPYAN [(4 1 R ,4 2 R ,10 1 R ,10 2 R )-3,5,9,11-tetraaza-1,7(2,6)-dipyridina-4,10(1,2)-dicyclohexanacyclododecaphane]. The X-ray crystal structures of Mn-PYAN and Mn-CHXPYAN evidence distorted octahedral geometries through coordination of the nitrogen atoms of the macrocycles. Cyclic voltammetry studies evidence reversible processes due to the Mn(II)/Mn(III) pair, indicating that the complexes are resistant to oxidation. CHXPYAN forms a more thermodynamically stable and kinetically inert Mn(II) complex than PYAN. Radiochemical studies with the radioactive isotope manganese-52 ( 52 Mn, t 1/2 = 5.6 days) evidenced better radiochemical yields for CHXPYAN than for PYAN. Both [ 52 Mn]Mn(II) complexes remained stable in mouse and human serum, so in vivo stability studies were carried out. Positron emission tomography/computed tomography scans and biodistribution assays indicated that [ 52 Mn]Mn-PYAN has a distribution pattern similar to that of [ 52 Mn]MnCl 2 , showing persistent radioactivity accumulation in the kidneys. Conversely, [ 52 Mn]Mn-CHXPYAN remained stable in vivo, clearing quickly from the liver and kidneys. |
