Association of NID2 SNPs with Glioma Risk and Prognosis in the Chinese Population.

Autor: Hao J; College of Life Sciences, Northwest University, Taibai Campus, No. 229, Taibai North Road, Beilin District, Xi'an, 710069, Shaanxi, China.; Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China.; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi, China., Huang C; Department of Gynaecology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China., Zhao W; College of Life Sciences, Northwest University, Taibai Campus, No. 229, Taibai North Road, Beilin District, Xi'an, 710069, Shaanxi, China.; Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China.; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi, China., Zhao L; College of Life Sciences, Northwest University, Taibai Campus, No. 229, Taibai North Road, Beilin District, Xi'an, 710069, Shaanxi, China., Hu X; College of Life Sciences, Northwest University, Taibai Campus, No. 229, Taibai North Road, Beilin District, Xi'an, 710069, Shaanxi, China.; Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China.; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi, China., Zhang W; College of Life Sciences, Northwest University, Taibai Campus, No. 229, Taibai North Road, Beilin District, Xi'an, 710069, Shaanxi, China.; Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China.; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi, China., Guo L; College of Life Sciences, Northwest University, Taibai Campus, No. 229, Taibai North Road, Beilin District, Xi'an, 710069, Shaanxi, China.; Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China.; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi, China., Dou X; College of Life Sciences, Northwest University, Taibai Campus, No. 229, Taibai North Road, Beilin District, Xi'an, 710069, Shaanxi, China.; Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China.; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi, China., Jin T; College of Life Sciences, Northwest University, Taibai Campus, No. 229, Taibai North Road, Beilin District, Xi'an, 710069, Shaanxi, China. jintb@nwu.edu.cn.; Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China. jintb@nwu.edu.cn.; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi, China. jintb@nwu.edu.cn., Hu M; College of Life Sciences, Northwest University, Taibai Campus, No. 229, Taibai North Road, Beilin District, Xi'an, 710069, Shaanxi, China. humingjun2020@163.com.; Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China. humingjun2020@163.com.; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi, China. humingjun2020@163.com.; Department of Neurosurgery, X'ian Changan District Hospital, Xi'an, Shaanxi, China. humingjun2020@163.com.
Jazyk: angličtina
Zdroj: Neuromolecular medicine [Neuromolecular Med] 2024 Jun 27; Vol. 26 (1), pp. 27. Date of Electronic Publication: 2024 Jun 27.
DOI: 10.1007/s12017-024-08795-0
Abstrakt: Glioma is the most common primary intracranial tumor with high mortality and poor prognosis. The purpose of this study was to investigate how single-nucleotide polymorphisms (SNPs) of the NID2 gene affect glioma risk and prognosis. Four candidate SNPs of NID2 in 529 glioma patients and 478 healthy controls were successfully genotyped by Agena MassARRAY mass spectrometer. Logistic regression was utilized to assess the associations between NID2 SNPs and glioma risk under different genetic models. Furthermore, the relationship between risk-related SNPs in NID2 and the prognosis of glioma patients was explored through Kaplan-Meier (KM) survival curve and Cox proportional hazard regression analysis. The results showed that rs11846847 (OR 1.24, p = 0.017) and rs1874569 (OR 1.22, p = 0.026) were significantly associated with an increased risk of glioma, and rs11846847 also had a risk-increasing effect on glioma in participants ≤ 40 years old. The interaction model of rs11846847 and rs1874569 could be more suitable for forecasting glioma risk. We also discovered a significant association between rs1874569 and poor prognosis in glioma patients (HR 1.32, p = 0.039) and especially CC genotype was relevant to shorter overall survival (OS) and progression-free survival (PFS) in patients with high-grade glioma. Additionally, the study demonstrated that gross total resection or chemotherapy improve glioma prognosis in the Chinese Han population. This study is the first to provide evidence for the association of NID2 SNPs with glioma risk and prognosis, suggesting that NID2 variants might be potential factors for glioma.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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