Testing the amount of nicotinamide mononucleotide and urolithin A as compared to the label claim.

Autor: Sandalova E; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117456, Singapore. sanelena@nus.edu.sg.; Centre for Healthy Longevity, National University Health System (NUHS), Singapore, Singapore. sanelena@nus.edu.sg., Li H; Centre of Innovation, for Complementary Health Product (COI-CHP) Temasek Polytechnic, Singapore, Singapore., Guan L; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117456, Singapore.; Centre for Healthy Longevity, National University Health System (NUHS), Singapore, Singapore., Raj SD; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117456, Singapore.; Centre for Healthy Longevity, National University Health System (NUHS), Singapore, Singapore.; Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore., Lim TG; Centre of Innovation, for Complementary Health Product (COI-CHP) Temasek Polytechnic, Singapore, Singapore., Tian E; Centre of Innovation, for Complementary Health Product (COI-CHP) Temasek Polytechnic, Singapore, Singapore., Kennedy BK; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117456, Singapore.; Centre for Healthy Longevity, National University Health System (NUHS), Singapore, Singapore.; Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore., Maier AB; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117456, Singapore. a.b.maier@vu.nl.; Centre for Healthy Longevity, National University Health System (NUHS), Singapore, Singapore. a.b.maier@vu.nl.; Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands. a.b.maier@vu.nl.
Jazyk: angličtina
Zdroj: GeroScience [Geroscience] 2024 Oct; Vol. 46 (5), pp. 5075-5083. Date of Electronic Publication: 2024 Jun 27.
DOI: 10.1007/s11357-024-01257-2
Abstrakt: Healthy Longevity Medicine aims to optimize health by targeting aging processes across the lifespan. Addressing accelerated aging involves adaptation of lifestyle and the use of geroprotective drugs and supplements, including nutritional supplements and bioactive compounds. The Food and Drug Administration, under the Dietary Supplement Health and Education Act, categorizes bioactive compounds and medicinal products as dietary supplements. While numerous companies sell ingredients that can be deemed geroprotectors, there's limited oversight in their quality control. Governmental safety authorities only verify the presence of prohibited compounds, not the accuracy of ingredients listed on labels.Here, Nicotinamide mononucleotide and Urolithin A supplements, easily accessible online or in pharmacies, were tested for their active ingredient content. Results showed a significant deviation from the labeled amounts, ranging from + 28.6% to -100%. This indicates a considerable disparity in the quality of geroprotective supplements.To address this variability, collaboration between and within societies representing healthcare professionals, industry and regulatory bodies is imperative to ensure the quality of geroprotective supplements.
(© 2024. The Author(s).)
Databáze: MEDLINE
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