Protective effects of pioglitazone in renal ischemia-reperfusion injury (RIRI): focus on oxidative stress and inflammation.

Autor: Golmohammadi M; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1988873554, Iran., Ivraghi MS; School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran., Hasan EK; College of Pharmacy, Al-Bayan University, Baghdad, Iraq., Huldani H; Department of Physiology, Faculty of Medicine Lambung, Mangkurat University, South Kalimantan, Banjarmasin, Indonesia., Zamanian MY; Urology and Nephrology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. mzamaniyan66@yahoo.com.; Department of Physiology, Hamadan University of Medical Sciences, Hamadan, 6718773654, Iran. mzamaniyan66@yahoo.com.; Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, 6718773654, Iran. mzamaniyan66@yahoo.com., Rouzbahani S; Miller School of Medicine, Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA.; Department of Community Medicine and Family Physician, School of Medicine, Isfahan University of Medical Sciences, Hezar Jarib Blvd, Isfahan, Iran., Mustafa YF; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq., Al-Hasnawi SS; College of Pharmacy, the Islamic University, 54001, Najaf, Iraq., Alazbjee AAA; College of Medicine, Al-Ayen University, Thi-Qar, Iraq., Khalajimoqim F; Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, 6718773654, Iran., Khalaj F; Digestive Diseases Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. khalajmd1992@gmail.com.
Jazyk: angličtina
Zdroj: Clinical and experimental nephrology [Clin Exp Nephrol] 2024 Oct; Vol. 28 (10), pp. 955-968. Date of Electronic Publication: 2024 Jun 27.
DOI: 10.1007/s10157-024-02525-3
Abstrakt: Background: Renal ischemia-reperfusion injury (RIRI) is a critical phenomenon that compromises renal function and is the most serious health concern related to acute kidney injury (AKI). Pioglitazone (Pio) is a known agonist of peroxisome proliferator-activated receptor-gamma (PPAR-γ). PPAR-γ is a nuclear receptor that regulates genes involved in inflammation, metabolism, and cellular differentiation. Activation of PPAR-γ is associated with antiinflammatory and antioxidant effects, which are relevant to the pathophysiology of RIRI. This study aimed to investigate the protective effects of Pio in RIRI, focusing on oxidative stress and inflammation.
Methods: We conducted a comprehensive literature search using electronic databases, including PubMed, ScienceDirect, Web of Science, Scopus, and Google Scholar.
Results: The results of this study demonstrated that Pio has antioxidant, anti-inflammatory, and anti-apoptotic activities that counteract the consequences of RIRI. The study also discussed the underlying mechanisms, including the modulation of various pathways such as TNF-α, NF-κB signaling systems, STAT3 pathway, KIM-1 and NGAL pathways, AMPK phosphorylation, and autophagy flux. Additionally, the study presented a summary of various animal studies that support the potential protective effects of Pio in RIRI.
Conclusion: Our findings suggest that Pio could protect the kidneys from RIRI by improving antioxidant capacity and decreasing inflammation. Therefore, these findings support the potential of Pio as a therapeutic strategy for preventing RIRI in different clinical conditions.
(© 2024. The Author(s), under exclusive licence to Japanese Society of Nephrology.)
Databáze: MEDLINE
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