[Brain-derived neurotrophic factor in the acute and early recovery period of ischemic stroke: the role of nocturnal hypoxemia].

Autor: Zabroda EN; Almazov National Medical Research Centre, St. Petersburg, Russia.; Saint Petersburg State University, St. Petersburg, Russia., Amelina VV; Almazov National Medical Research Centre, St. Petersburg, Russia.; Herzen State Pedagogical University, St. Petersburg, Russia., Gordeev AD; Almazov National Medical Research Centre, St. Petersburg, Russia.; Saint Petersburg State University, St. Petersburg, Russia., Sakovsky IV; Saint Petersburg Medical and Social Institute, St. Petersburg, Russia., Bochkarev MV; Almazov National Medical Research Centre, St. Petersburg, Russia., Kolomeichuk SN; Institute of Biology of Karelian Research Centre, Petrozavodsk, Russia., Kayumova EE; Almazov National Medical Research Centre, St. Petersburg, Russia., Vasilieva EY; Almazov National Medical Research Centre, St. Petersburg, Russia., Sviryaev YV; Almazov National Medical Research Centre, St. Petersburg, Russia., Korostovtseva LS; Almazov National Medical Research Centre, St. Petersburg, Russia.
Jazyk: ruština
Zdroj: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2024; Vol. 124 (5. Vyp. 2), pp. 72-78.
DOI: 10.17116/jnevro202412405272
Abstrakt: Objective: To study the relationship between brain-derived neurotrophic factor (BDNF) and the severity of nocturnal hypoxemia in patients in the acute and early recovery period of ischemic stroke (IS).
Material and Methods: We enrolled 44 patients (27 men, 17 women), aged 18-85 years, in the acute phase of IS. At 3-month follow-up, 35 people were examined (21 men and 14 women). In the acute period, in addition to routine diagnostic procedures, respiratory monitoring was carried out, and the serum level of BDNF was measured by enzyme-linked immunosorbent assay. BDNF level was also evaluated at 3-month follow-up visit. Neurological status and its dynamics in the acute period of stroke were assessed as part of the clinical routine according to the National Institutes of Health Stroke Scale (NIHSS) at admission and discharge.
Results: We found a direct correlation between the duration of hypoxemia with SpO 2 less than 90% ( r =0.327, p =0.035) and less than 85% ( r =0.461, p =0.003) and BDNF level in the acute phase of IS. BDNF level in the acute period of IS was negatively correlated with the minimum saturation value ( r =-0.328, p =0.034). There was a direct relationship between BDNF level in the early recovery period and the duration of hypoxemia with SpO 2 less than 85% ( r =-0.389, p =0.028). A regression model showed that BDNF level was associated with the minimum SpO 2 level. No significant associations were found with indicators of sleep-disordered breathing severity, such as the apnea-hypopnea index and the oxygen desaturation index.
Conclusion: The severity of nocturnal hypoxemia is associated with the increase in BDNF levels both in the acute and recovery periods of IS, regardless of the presence of concomitant breathing disorders during sleep.
Databáze: MEDLINE
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