Shape modelling reveals age-related knee bony shape changes in asymptomatic knees.

Autor: Nguyen K; School of Medicine and Psychology, Australian National University, Canberra, Australia., Perriman DM; School of Medicine and Psychology, Australian National University, Canberra, Australia.; Trauma and Orthopaedic Research Unit (TORU), The Canberra Hospital, Canberra, Australia., Scarvell JM; University of Canberra, Canberra, Australia., Pickering MR; School of Engineering and Information Technology, UNSW Canberra, Canberra, Australia., Galvin CR; College of Engineering, Computing and Cybernetics, Australian National University, Canberra, Australia., Smith PN; School of Medicine and Psychology, Australian National University, Canberra, Australia.; Trauma and Orthopaedic Research Unit (TORU), The Canberra Hospital, Canberra, Australia., Lynch JT; School of Medicine and Psychology, Australian National University, Canberra, Australia.; Trauma and Orthopaedic Research Unit (TORU), The Canberra Hospital, Canberra, Australia.
Jazyk: angličtina
Zdroj: Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2024 Nov; Vol. 42 (11), pp. 2507-2513. Date of Electronic Publication: 2024 Jun 27.
DOI: 10.1002/jor.25923
Abstrakt: Osteoarthritis (OA) causes bony shape changes within the knee. Furthermore, the risk of developing OA increases with age. However, age alone does not cause OA. It is therefore important to understand the healthy age-related trajectories of knee shape before attributing these changes to OA. The aim of this study was to determine the association between bony knee shape and age using statistical-shape modelling (SSM). 96 participants received a CT scan of their knee. Three-dimensional models were created using manual segmentation. Separate SSM's for the distal femur and proximal tibia were created. Linear regression models were used to assess the association between age and femoral and tibial shape. Fourteen modes of the femoral and tibial SSM's captured 68% and 73% shape variation, respectively. Only femoral mode 3 and tibial mode 7 were associated with age. Increasing age was related to larger femoral bone volume and deepening of the femoral trochlear groove. Furthermore, increased age was associated with medial tibial plateau expansion. Aspects of bony femoral and tibial shape were significantly associated with aging, including femoral and tibial bone size, femoral trochlear groove, and medial tibial plateau area. Changes in knee morphology occur as a normal process of aging without osteoarthritis development. This may be a response to mechanical loading over time. Further research investigating the effect of these changes on loading in the knee may provide valuable information for knee health in older age.
(© 2024 The Author(s). Journal of Orthopaedic Research® published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society.)
Databáze: MEDLINE
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