An Analysis of Antibody Response to COVID-19 Vaccination Among Medicos in a Predominantly Tribal State in India: A Comparative Study.

Autor:	Kiran KA; Preventive Medicine, Rajendra institute of Medical Sciences, Ranchi, IND., Kumari S; Blood Bank, Rajendra Institute of Medical Sciences, Ranchi, IND., Saroj U; Blood Bank, Rajendra institute of Medical Sciences, Ranchi, IND., Kujur M; Preventive Medicine, Rajendra institute of Medical Sciences, Ranchi, IND., Kujur A; Community Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND., Kumar M; Community Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND., Narain S; Preventive and Social Medicine, Rajendra institute of Medical Sciences, Ranchi, IND., N V; Community Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND., K J; Preventive and Social Medicine, Rajendra institute of Medical Sciences, Ranchi, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 May 27; Vol. 16 (5), pp. e61154. Date of Electronic Publication: 2024 May 27 (Print Publication: 2024).
DOI:	10.7759/cureus.61154
Abstrakt:	Introduction Global health is still being impacted by the coronavirus disease 2019 (COVID-19) pandemic. Objectives We evaluated the antibody response in this study in individuals who received two doses of the COVID-19 vaccination, both with and without a history of SARS-CoV-2 infection. Methodology It was a hospital-based cross-sectional study conducted among healthcare personnel at a tertiary institution of a predominantly tribal state in India. Results A total of 187 medical students made up the vaccinee group; the majority (152; 81.3%) were between the ages of 18 and 23; 128 (68.4%) of the students were female; and 104 (55.6%) had received the Covishield (AstraZeneca plc, England, UK) vaccination. Of the subjects, 51 (27.3%) had a history of COVID-19 infection. For those who were infected, the antibody titer peaked after six months, whereas it took twice as long for those who were not. Up to a year later, the antibody titers for Covaxin (Bharat Biotech, Hyderabad, India) and Covishield remained equal; however, Covishield titers drastically decreased while Covaxin stayed constant when an infection history was present. Conclusion The study's findings show that immunization in individuals who have previously contracted COVID-19 induces a higher level of antibody response than immunization in individuals who have not previously contracted the virus. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Institutional Ethics Committee, Rajendra Institute of Medical Sciences issued approval 395, dated 07/12/2021. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Kiran et al.)
Databáze:	MEDLINE
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