Electrospun skin dressings for diabetic wound treatment: a systematic review.

Autor: de Souza A; Department of Biosciences, Federal University of São Paulo (UNIFESP), 136 Silva Jardim Street, Santos, SP 11015020 Brazil., Santo GE; Department of Biosciences, Federal University of São Paulo (UNIFESP), 136 Silva Jardim Street, Santos, SP 11015020 Brazil., Amaral GO; Department of Biosciences, Federal University of São Paulo (UNIFESP), 136 Silva Jardim Street, Santos, SP 11015020 Brazil., Sousa KSJ; Department of Biosciences, Federal University of São Paulo (UNIFESP), 136 Silva Jardim Street, Santos, SP 11015020 Brazil., Parisi JR; Metropolitan University of Santos (UNIMES), 8 Francisco Glicerio Avenue, Santos, SP 11045002 Brazil., Achilles RB; Department of Biosciences, Federal University of São Paulo (UNIFESP), 136 Silva Jardim Street, Santos, SP 11015020 Brazil., Ribeiro DA; Department of Biosciences, Federal University of São Paulo (UNIFESP), 136 Silva Jardim Street, Santos, SP 11015020 Brazil., Renno ACM; Department of Biosciences, Federal University of São Paulo (UNIFESP), 136 Silva Jardim Street, Santos, SP 11015020 Brazil.
Jazyk: angličtina
Zdroj: Journal of diabetes and metabolic disorders [J Diabetes Metab Disord] 2023 Oct 17; Vol. 23 (1), pp. 49-71. Date of Electronic Publication: 2023 Oct 17 (Print Publication: 2024).
DOI: 10.1007/s40200-023-01324-z
Abstrakt: Abstract: Diabetes mellitus is a metabolic disease characterized by persistent hyperglycemia associated with a lack of insulin production or insulin resistance. In diabetic patients, the capacity for healing is generally decreased, leading to chronic wounds. One of the most common treatments for chronic wounds is skin dressings, which serve as protection from infection, reduce pain levels, and stimulate tissue healing. Furthermore, electrospinning is one of the most effective techniques used for manufacturing skin dressings.
Objective: The purpose of this study was to perform a systematic review of the literature to examine the effects of electrospun skin dressings from different sources in the process of healing skin wounds using in vivo experiments in diabetic rats.
Methods: The search was carried out according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and the Medical Subject Headings (MeSH) descriptors were defined as "wound dressing," "diabetes," "in vivo," and "electrospun." A total of 14 articles were retrieved from PubMed and Scopus databases.
Results: The results were based mainly on histological analysis and macroscopic evaluation, demonstrating moderate evidence synthesis for all experimental studies, showing a positive effect of electrospun skin dressings for diabetic wound treatment.
Conclusion: This review confirms the significant benefits of using electrospun skin dressings for skin repair and regeneration. All the inks used were demonstrated to be suitable for dressing manufacturing. Moreover, in vivo findings showed full wound closure in most of the studies, with well-organized dermal and epidermal layers.
Competing Interests: Conflict of interestThe authors declare that there is no conflict of interest.
(© The Author(s), under exclusive licence to Tehran University of Medical Sciences 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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