| Autor: |
Pinheiro VDS; Nutrition and Exercise Metabolism Research Group, Multidisciplinary Center, Nutrition Institute, Federal University of Rio de Janeiro, Macaé 27971-525, RJ, Brazil.; Postgraduate Program in Food Science, Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-909, RJ, Brazil., Junior OJFR; Nutrition and Exercise Metabolism Research Group, Multidisciplinary Center, Nutrition Institute, Federal University of Rio de Janeiro, Macaé 27971-525, RJ, Brazil.; Multicenter Postgraduate Program in Physiological Sciences, Federal University of Rio de Janeiro, Macaé 27965-045, RJ, Brazil., Ortmann CF; Sabinsa Brasil Ltd., Florianópolis 88020-302, SC, Brazil., Pande A; Sabinsa Corporation, 20 Lake Drive, East Windsor, NJ 08520, USA., Conte-Junior CA; Postgraduate Program in Food Science, Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-909, RJ, Brazil., Alvares TS; Nutrition and Exercise Metabolism Research Group, Multidisciplinary Center, Nutrition Institute, Federal University of Rio de Janeiro, Macaé 27971-525, RJ, Brazil.; Multicenter Postgraduate Program in Physiological Sciences, Federal University of Rio de Janeiro, Macaé 27965-045, RJ, Brazil.; Multidisciplinary Center, Food and Nutrition Institute, Federal University of Rio de Janeiro, Macaé 27930-560, RJ, Brazil. |
| Abstrakt: |
In recent years, there has been a notable surge in the popularity of beetroot-based dietary supplements, driven by their rich nitrate composition. Several types of beetroot-based dietary supplements can be found in markets worldwide; however, ensuring the safety of dietary supplements is a crucial consideration, as there is limited evidence on their safety, especially for older populations. Therefore, the purpose of the current study was to evaluate the safety and tolerability of a nitrate-rich beetroot extract in older participants taking supplements over 12 weeks. The participants were randomly assigned to receive 20 g daily of beetroot extract or a matching placebo. The safety and tolerability of the supplementation were evaluated as the occurrence of adverse events and anthropometric, biochemical, and hemodynamic parameters were measured. No serious adverse events were reported in any group. Anthropometric, biochemical, and hemodynamic parameter changes between the baseline and the end of the study were not statistically significant in either group. However, interestingly, the group receiving beetroot extract supplementation exhibited a notable increase in plasma nitrate levels ( p = 0.076, f = 0.50) and showed a decrease in insulin levels ( p = 0.026, f = 0.59). In conclusion, we found that 20 g of beetroot extract supplementation for 12 weeks was safe and well tolerated in older participants. |
