| Autor: |
Cayabyab KB; Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 84602, USA., Shin MJ; Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 84602, USA., Heimuli MS; Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 84602, USA., Kim IJ; Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 84602, USA., D'Agostino DP; Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33602, USA., Johnson RJ; Department of Medicine, University of Colorado, Aurora, CO 80045, USA., Koutnik AP; Sansum Diabetes Research Institute, Santa Barbara, CA 93105, USA., Bellissimo N; School of Nutrition, Toronto Metropolitan University, Toronto, ON M5S 1A8, Canada., Diamond DM; Department of Psychology, University of South Florida, Tampa, FL 33602, USA., Norwitz NG; Harvard Medical School, Boston, MA 02115, USA., Arroyo JA; Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 84602, USA., Reynolds PR; Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 84602, USA., Bikman BT; Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 84602, USA. |
| Abstrakt: |
The global rise in type 2 diabetes (T2D) and obesity necessitates innovative dietary interventions. This study investigates the effects of allulose, a rare sugar shown to reduce blood glucose, in a rat model of diet-induced obesity and T2D. Over 12 weeks, we hypothesized that allulose supplementation would improve body weight, insulin sensitivity, and glycemic control. Our results showed that allulose mitigated the adverse effects of high-fat, high-sugar diets, including reduced body weight gain and improved insulin resistance. The allulose group exhibited lower food consumption and increased levels of glucagon-like peptide-1 (GLP-1), enhancing glucose regulation and appetite control. Additionally, allulose prevented liver triglyceride accumulation and promoted mitochondrial uncoupling in adipose tissue. These findings suggest that allulose supplementation can improve metabolic health markers, making it a promising dietary component for managing obesity and T2D. Further research is needed to explore the long-term benefits and mechanisms of allulose in metabolic disease prevention and management. This study supports the potential of allulose as a safe and effective intervention for improving metabolic health in the context of dietary excess. |
