| Autor: |
Radulović NS; Department of Chemistry, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia., Mladenović MZ; Department of Chemistry, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia., Lima CS; Department of Biological Sciences and Health, Federal University of Amapá, Highway Juscelino Kubitschek, Km 02, Macapá 68903-197, Brazil.; Postgraduate Program in Health Sciences, Federal University of Amapá, Highway Juscelino Kubitschek, Km 02, Macapá 68903-197, Brazil., Müller ECA; Department of Biological Sciences and Health, Federal University of Amapá, Highway Juscelino Kubitschek, Km 02, Macapá 68903-197, Brazil., da Costa EVM; Department of Biological Sciences and Health, Federal University of Amapá, Highway Juscelino Kubitschek, Km 02, Macapá 68903-197, Brazil., Martins RV; Postgraduate Program in Health Sciences, Federal University of Amapá, Highway Juscelino Kubitschek, Km 02, Macapá 68903-197, Brazil., Boylan F; School of Pharmacy and Pharmaceutical Sciences, Panoz Institute, and Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, D02 PN40 Dublin, Ireland. |
| Abstrakt: |
Motivated by the culinary and ethnopharmacological use of Acmella oleracea (L.) R.K. Jansen, this study aimed to unveil new chemical compounds from its essential oil (EO). Acmella oleracea , known for its anesthetic and spicy properties, has been used in traditional medicine and cuisine, particularly in Northern Brazil. Through a detailed GC-MS analysis, 180 constituents were identified, including 12 tentatively identified long-chain α-keto esters of various acids. Additionally, 18 new esters were synthesized for structural verification. This research expands the known chemical diversity of A. oleracea EO, providing a basis for potential pharmacological applications. The identification of new natural products, including homologs and analogs of acmellonate, underscores the EO's rich chemical profile and its potential for novel bioproduct development. |
