Nanoparticles as Drug Delivery Systems for the Targeted Treatment of Atherosclerosis.

Autor: Pang AS; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore., Dinesh T; Department of Medicine, Government Kilpauk Medical College, Chennai 600010, Tamilnadu, India., Pang NY; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore., Dinesh V; Department of Pathology, Dhanalakshmi Srinivasan Medical College Hospital, Perambalur 621113, Tamilnadu, India., Pang KY; Division of Medicine, South Australia Health, Northern Adelaide Local Health Network, Adelaide, SA 5112, Australia., Yong CL; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore., Lee SJJ; Division of Medicine, South Australia Health, Northern Adelaide Local Health Network, Adelaide, SA 5112, Australia., Yip GW; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117594, Singapore., Bay BH; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117594, Singapore., Srinivasan DK; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117594, Singapore.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2024 Jun 17; Vol. 29 (12). Date of Electronic Publication: 2024 Jun 17.
DOI: 10.3390/molecules29122873
Abstrakt: Atherosclerosis continues to be a leading cause of morbidity and mortality globally. The precise evaluation of the extent of an atherosclerotic plaque is essential for forecasting its likelihood of causing health concerns and tracking treatment outcomes. When compared to conventional methods used, nanoparticles offer clear benefits and excellent development opportunities for the detection and characterisation of susceptible atherosclerotic plaques. In this review, we analyse the recent advancements of nanoparticles as theranostics in the management of atherosclerosis, with an emphasis on applications in drug delivery. Furthermore, the main issues that must be resolved in order to advance clinical utility and future developments of NP research are discussed. It is anticipated that medical NPs will develop into complex and advanced next-generation nanobotics that can carry out a variety of functions in the bloodstream.
Databáze: MEDLINE
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