| Autor: |
Lo Greco MC; Radiation Oncology Unit, Department of Biomedical, Dental and Morphological and Functional Imaging Sciences, University of Messina, 98122 Messina, Italy., Marano G; Radiation Oncology Unit, Department of Biomedical, Dental and Morphological and Functional Imaging Sciences, University of Messina, 98122 Messina, Italy., Milazzotto R; Radiation Oncology Unit, University Hospital Policlinico 'G. Rodolico-San Marco', 95123 Catania, Italy., Liardo RLE; Radiation Oncology Unit, University Hospital Policlinico 'G. Rodolico-San Marco', 95123 Catania, Italy., Finocchiaro I; Radiation Oncology Unit, Department of Biomedical, Dental and Morphological and Functional Imaging Sciences, University of Messina, 98122 Messina, Italy., La Rocca M; Radiation Oncology Unit, Department of Biomedical, Dental and Morphological and Functional Imaging Sciences, University of Messina, 98122 Messina, Italy., Basile A; Radiology I Unit, University Hospital Policlinico 'G. Rodolico-San Marco', 95123 Catania, Italy.; Department of Medical Surgical Sciences and Advanced Technologies 'G.F. Ingrassia', University of Catania, 95123 Catania, Italy., Foti PV; Radiology I Unit, University Hospital Policlinico 'G. Rodolico-San Marco', 95123 Catania, Italy.; Department of Medical Surgical Sciences and Advanced Technologies 'G.F. Ingrassia', University of Catania, 95123 Catania, Italy., Palmucci S; Radiology I Unit, University Hospital Policlinico 'G. Rodolico-San Marco', 95123 Catania, Italy.; Department of Medical Surgical Sciences and Advanced Technologies 'G.F. Ingrassia', University of Catania, 95123 Catania, Italy., David E; Radiology I Unit, University Hospital Policlinico 'G. Rodolico-San Marco', 95123 Catania, Italy.; Department of Medical Surgical Sciences and Advanced Technologies 'G.F. Ingrassia', University of Catania, 95123 Catania, Italy., Pergolizzi S; Radiation Oncology Unit, Department of Biomedical, Dental and Morphological and Functional Imaging Sciences, University of Messina, 98122 Messina, Italy., Spatola C; Radiation Oncology Unit, University Hospital Policlinico 'G. Rodolico-San Marco', 95123 Catania, Italy.; Department of Medical Surgical Sciences and Advanced Technologies 'G.F. Ingrassia', University of Catania, 95123 Catania, Italy. |
| Abstrakt: |
In this retrospective case series, we investigate the synergistic effect and the immunomodulatory potential of combination radiotherapy and immunotherapy on 11 patients affected by locally advanced or metastatic cutaneous squamous cell carcinoma (CSCC), treated at our institution between 2020 and 2023. The primary endpoints of this study are objective tumor response, assessed by Immunotherapy Response Evaluation Criteria in Solid Tumors (iRECIST), and time to treatment failure (disease progression). In all patients, surgery was deemed not amenable, due to its potential functional and aesthetic impact. Therefore, upon multidisciplinary agreement, radiotherapy and immunotherapy with cemiplimab were alternatively administered. After 6 months, an early objective tumor response was observed in 9/11 patients, with 17/20 cutaneous lesions (85%) presenting either a complete or partial response. Only 2/11 patients, with a total of 3/20 cutaneous lesions (15%), had stable disease. These benefits persisted at a longer follow-up (21.4 ± 9.7 months), with no patients presenting disease progression. Despite the retrospective nature of this study and small sample size, our experience highlights the ability of concomitant radiotherapy and cemiplimab to promote an early objective response in patients with advanced CSCC. Moreover, in our population, the clinical benefits were also related to a longer progression-free survival, without any safety alert reported. |
