Diagnostic Performance of Plasma SP-D, KL-6, and CC16 in Acutely Hospitalised Patients Suspected of Having Community-Acquired Pneumonia-A Diagnostic Accuracy Study.

Autor: Heltborg A; Department of Emergency Medicine, University Hospital of Southern Denmark, 6200 Aabenraa, Denmark.; Department of Regional Health Research, University of Southern Denmark, 5230 Odense, Denmark., Mogensen CB; Department of Emergency Medicine, University Hospital of Southern Denmark, 6200 Aabenraa, Denmark.; Department of Regional Health Research, University of Southern Denmark, 5230 Odense, Denmark., Andersen ES; Department of Regional Health Research, University of Southern Denmark, 5230 Odense, Denmark.; Department of Biochemistry and Immunology, Lillebaelt Hospital, University Hospital of Southern Denmark, 7100 Vejle, Denmark., Cartuliares MB; Department of Emergency Medicine, University Hospital of Southern Denmark, 6200 Aabenraa, Denmark.; Department of Regional Health Research, University of Southern Denmark, 5230 Odense, Denmark., Petersen ERB; Department of Biochemistry and Immunology, Lillebaelt Hospital, University Hospital of Southern Denmark, 7100 Vejle, Denmark.; Department of Blood Tests, Biochemistry and Immunology, University Hospital of Southern Denmark, 6200 Aabenraa, Denmark., Skovsted TA; Department of Blood Tests, Biochemistry and Immunology, University Hospital of Southern Denmark, 6200 Aabenraa, Denmark., Posth S; Department of Clinical Research, University of Southern Denmark, 5230 Odense, Denmark.; Department of Emergency Medicine, Odense University Hospital, 5000 Odense, Denmark., Graumann O; Department of Radiology, Aarhus University Hospital, 8200 Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark., Lorentzen MJ; Department of Emergency Medicine, University Hospital of Southern Denmark, 6200 Aabenraa, Denmark.; Department of Regional Health Research, University of Southern Denmark, 5230 Odense, Denmark., Hertz MA; Department of Clinical Research, University of Southern Denmark, 5230 Odense, Denmark.; Department of Emergency Medicine, Odense University Hospital, 5000 Odense, Denmark.; Department of Infectious Diseases, Odense University Hospital, 5000 Odense, Denmark., Brasen CL; Department of Regional Health Research, University of Southern Denmark, 5230 Odense, Denmark.; Department of Biochemistry and Immunology, Lillebaelt Hospital, University Hospital of Southern Denmark, 7100 Vejle, Denmark., Skjøt-Arkil H; Department of Emergency Medicine, University Hospital of Southern Denmark, 6200 Aabenraa, Denmark.; Department of Regional Health Research, University of Southern Denmark, 5230 Odense, Denmark.
Jazyk: angličtina
Zdroj: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2024 Jun 17; Vol. 14 (12). Date of Electronic Publication: 2024 Jun 17.
DOI: 10.3390/diagnostics14121283
Abstrakt: Community-acquired pneumonia is a common cause of acute hospitalisation. Identifying patients with community-acquired pneumonia among patients suspected of having the disease can be a challenge, which causes unnecessary antibiotic treatment. We investigated whether the circulatory pulmonary injury markers surfactant protein D (SP-D), Krebs von den Lungen-6 (KL-6), and Club cell protein 16 (CC16) could help identify patients with community-acquired pneumonia upon acute admission. In this multi-centre diagnostic accuracy study, SP-D, KL-6, and CC16 were quantified in plasma samples from acutely hospitalised patients with provisional diagnoses of community-acquired pneumonia. The area under the receiver operator characteristics curve (AUC) was calculated for each marker against the following outcomes: patients' final diagnoses regarding community-acquired pneumonia assigned by an expert panel, and pneumonic findings on chest CTs. Plasma samples from 339 patients were analysed. The prevalence of community-acquired pneumonia was 63%. AUCs for each marker against both final diagnoses and chest CT diagnoses ranged between 0.50 and 0.56. Thus, SP-D, KL-6, and CC16 demonstrated poor diagnostic performance for community-acquired pneumonia in acutely hospitalised patients. Our findings indicate that the markers cannot readily assist physicians in confirming or ruling out community-acquired pneumonia.
Databáze: MEDLINE
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