| Autor: |
Szodorai R; Department of Pathology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540139 Targu Mures, Romania.; Department of Pathology, Clinical County Emergency Hospital Targu Mures, 540140 Targu Mures, Romania., Banias L; Department of Pathology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540139 Targu Mures, Romania.; Department of Pathology, Clinical County Emergency Hospital Targu Mures, 540140 Targu Mures, Romania., Kovalszky I; Department of Pathology and Experimental Cancer Research, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary., Dezső K; Department of Pathology and Experimental Cancer Research, Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary., Kovács Z; Department of Pathology, Clinical County Emergency Hospital Targu Mures, 540140 Targu Mures, Romania.; Research Center of Oncopathology and Translational Research (CCOMT), 540139 Targu Mures, Romania., Gurzu S; Department of Pathology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540139 Targu Mures, Romania.; Department of Pathology, Clinical County Emergency Hospital Targu Mures, 540140 Targu Mures, Romania.; Research Center of Oncopathology and Translational Research (CCOMT), 540139 Targu Mures, Romania.; Romanian Academy of Medical Sciences, 030167 Bucharest, Romania. |
| Abstrakt: |
It is known that V-set and immunoglobulin domain containing 1 (VSIG1) is a cell-cell adhesion molecule that can serve as an indicator of better survival in patients with gastric cancer. Its interaction with cytoplasmic thyroid transcription factor 1 (TTF-1) has been hypothesized to characterize gastric-type HCC, but its clinical importance is far from understood. As VSIG1 has also been supposed to be involved in the epithelial-mesenchymal transition (EMT) phenomenon, we checked for the first time in the literature the supposed interaction between VSIG1, TTF-1, and Vimentin (VIM) in HCCs. Immunohistochemical (IHC) stains were performed on 217 paraffin-embedded tissue samples that included tumor cells and normal hepatocytes, which served as positive internal controls. VSIG1 positivity was seen in 113 cases (52.07%). In 71 out of 217 HCCs (32.71%), simultaneous positivity for VSIG1 and TTF-1 was seen, being more specific for G1/G2 carcinomas with a trabecular architecture and a longer OS ( p = 0.004). A negative association with VIM was revealed ( p < 0.0001). Scirrhous-type HCC proved negative for all three examined markers. The present paper validates the hypothesis of the existence of a gastric-type HCC, which shows a glandular-like architecture and is characterized by double positivity for VSIG1 and TTF-1, vimentin negativity, and a significant OS. |
