Relationship between Hypoxia and Hypercapnia Tolerance and Life Expectancy.

Autor: Tregub PP; Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia.; Brain Science Institute, Research Center of Neurology, 125367 Moscow, Russia.; Scientific and Educational Resource Center 'Innovative Technologies of Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis', RUDN University, 117198 Moscow, Russia., Komleva YK; Brain Science Institute, Research Center of Neurology, 125367 Moscow, Russia., Kulikov VP; Department of Ultrasound and Functional Diagnostics, Altay State Medical University, 656040 Barnaul, Russia., Chekulaev PA; Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia., Tregub OF; Independent Researcher, 127055 Moscow, Russia., Maltseva LD; Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia., Manasova ZS; Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia., Popova IA; Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia., Andriutsa NS; Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia., Samburova NV; Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia., Salmina AB; Brain Science Institute, Research Center of Neurology, 125367 Moscow, Russia., Litvitskiy PF; Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 13; Vol. 25 (12). Date of Electronic Publication: 2024 Jun 13.
DOI: 10.3390/ijms25126512
Abstrakt: The review discusses the potential relationship between hypoxia resistance and longevity, the influence of carbon dioxide on the mechanisms of aging of the mammalian organism, and intermittent hypercapnic-hypoxic effects on the signaling pathways of aging mechanisms. In the article, we focused on the potential mechanisms of the gero-protective efficacy of carbon dioxide when combined with hypoxia. The review summarizes the possible influence of intermittent hypoxia and hypercapnia on aging processes in the nervous system. We considered the perspective variants of the application of hypercapnic-hypoxic influences for achieving active longevity and the prospects for the possibilities of developing hypercapnic-hypoxic training methods.
Databáze: MEDLINE
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