| Autor: |
Tiwari PK; Biological and Bio-Computational Lab, Department of Life Science, School of Basic Sciences and Research, Sharda University, Greater Noida 201310, Uttar Pradesh, India., Shanmugam P; Amity Institute of Biotechnology, Amity University, Mumbai 410206, Maharashtra, India., Karn V; Amity Institute of Biotechnology, Amity University, Mumbai 410206, Maharashtra, India., Gupta S; Department of Biotechnology, GLA University, Mathura 281406, Uttar Pradesh, India., Mishra R; Department of Computer Engineering, Parul University, Ta. Waghodia, Vadodara 391760, Gujarat, India., Rustagi S; School of Applied and Life science, Uttaranchal University, Dehradun 248007, Uttarakhand, India., Chouhan M; Biological and Bio-Computational Lab, Department of Life Science, School of Basic Sciences and Research, Sharda University, Greater Noida 201310, Uttar Pradesh, India., Verma D; Department of Biotechnology, Graphic Era (Deemed to be University), Dehradun 248002, Uttarakhand, India., Jha NK; Centre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 602105, Tamil Nadu, India.; School of Bioengineering & Biosciences, Lovely Professional University, Phagwara 144411, Punjab, India.; Department of Biotechnology, Sharda School of Engineering and Technology, Sharda University, Greater Noida 201310, Uttar Pradesh, India., Kumar S; Biological and Bio-Computational Lab, Department of Life Science, School of Basic Sciences and Research, Sharda University, Greater Noida 201310, Uttar Pradesh, India. |
| Abstrakt: |
Pancreatic cancer is a prevalent lethal gastrointestinal cancer that generally does not show any symptoms until it reaches advanced stages, resulting in a high mortality rate. People at high risk, such as those with a family history or chronic pancreatitis, do not have a universally accepted screening protocol. Chemotherapy and radiotherapy demonstrate limited effectiveness in the management of pancreatic cancer, emphasizing the urgent need for innovative therapeutic strategies. Recent studies indicated that the complex interaction among pancreatic cancer cells within the dynamic microenvironment, comprising the extracellular matrix, cancer-associated cells, and diverse immune cells, intricately regulates the biological characteristics of the disease. Additionally, mounting evidence suggests that EVs play a crucial role as mediators in intercellular communication by the transportation of different biomolecules, such as miRNA, proteins, DNA, mRNA, and lipids, between heterogeneous cell subpopulations. This communication mediated by EVs significantly impacts multiple aspects of pancreatic cancer pathogenesis, including proliferation, angiogenesis, metastasis, and resistance to therapy. In this review, we delve into the pivotal role of EV-associated miRNAs in the progression, metastasis, and development of drug resistance in pancreatic cancer as well as their therapeutic potential as biomarkers and drug-delivery mechanisms for the management of pancreatic cancer. |
