Interleukin-1α as a Potential Prognostic Biomarker in Pancreatic Cancer.

Autor:	Gigante L; Platform of Transfer in Biological Oncology, Georges François Leclerc Cancer Center-Unicancer, 1 Rue du Professeur Marion, 21000 Dijon, France.; UFR of Health Sciences, University of Burgundy, 21000 Dijon, France., Gaudillière-Le Dain G; Platform of Transfer in Biological Oncology, Georges François Leclerc Cancer Center-Unicancer, 1 Rue du Professeur Marion, 21000 Dijon, France.; UFR of Health Sciences, University of Burgundy, 21000 Dijon, France., Bertaut A; Biostatistics and Methodology Unit, Georges-François Leclerc Cancer Center, 21000 Dijon, France., Truntzer C; Platform of Transfer in Biological Oncology, Georges François Leclerc Cancer Center-Unicancer, 1 Rue du Professeur Marion, 21000 Dijon, France.; UMR INSERM 1231, 7 Boulevard Jeanne d'Arc, 21000 Dijon, France.; Genomic and Immunotherapy Medical Institute, Dijon University Hospital, 14 Rue Paul Gaffarel, 21000 Dijon, France., Ghiringhelli F; Platform of Transfer in Biological Oncology, Georges François Leclerc Cancer Center-Unicancer, 1 Rue du Professeur Marion, 21000 Dijon, France.; UFR of Health Sciences, University of Burgundy, 21000 Dijon, France.; UMR INSERM 1231, 7 Boulevard Jeanne d'Arc, 21000 Dijon, France.; Genomic and Immunotherapy Medical Institute, Dijon University Hospital, 14 Rue Paul Gaffarel, 21000 Dijon, France.; Department of Medical Oncology, Georges-François Leclerc Cancer Center, 1 Rue du Professeur Marion, 21000 Dijon, France.
Jazyk:	angličtina
Zdroj:	Biomedicines [Biomedicines] 2024 May 30; Vol. 12 (6). Date of Electronic Publication: 2024 May 30.
DOI:	10.3390/biomedicines12061216
Abstrakt:	Purpose: We assessed the prognostic role of pro-inflammatory cytokines of the IL-1 superfamily in patients with pancreatic cancer. Methods: This retrospective study was performed using two independent cohorts of patients with pancreatic cancer: the International Cancer Genome Consortium (ICGC, N = 267) cohort and The Cancer Genome Atlas (TCGA, N = 178) cohort. Univariate Cox regressions were used to identify prognosis-related pro-inflammatory cytokines of the IL-1 superfamily. Cytokines associated with outcome were included in a multivariate Cox model with relevant clinicopathological variables to identify prognostic biomarkers. Results: IL-1α was the only pro-inflammatory cytokine of the IL-1 superfamily that was significantly associated with prognosis in both cohorts. In the training cohort (ICGC), the decile of patients with the lowest IL1A expression had better overall survival (HR = 1.99 [1.01-3.93], p = 0.05) and better relapse-free survival (HR = 1.85 [1.02-3.34], p = 0.04) than the group with the highest IL1A expression. The validation cohort (TCGA) confirmed these results: the decile with the lowest IL1A expression had better overall survival (HR = 3.00 [1.14-7.90], p = 0.03) and a lower risk of progression (HR = 3.11 [1.24-7.80], p = 0.01). Conclusions: IL1A is an independent prognostic marker and could be considered a potential therapeutic target in pancreatic cancer patients.
Databáze:	MEDLINE
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