Synaptic architecture of leg and wing premotor control networks in Drosophila.

Autor: Lesser E; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA., Azevedo AW; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA., Phelps JS; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.; Neuroengineering Laboratory, Brain Mind Institute and Institute of Bioengineering, EPFL, Lausanne, Switzerland., Elabbady L; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA., Cook A; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA., Syed DS; University of California, Santa Barbara, CA, USA., Mark B; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA., Kuroda S; Department of Neurobiology, Harvard Medical School, Boston, MA, USA., Sustar A; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA., Moussa A; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA., Dallmann CJ; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA., Agrawal S; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA., Lee SJ; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA., Pratt B; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA., Skutt-Kakaria K; California Institute of Technology, Pasadena, CA, USA., Gerhard S; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.; UniDesign Solutions LLC, Zurich, Switzerland., Lu R; Zetta AI, LLC, Sherrill, NY, USA., Kemnitz N; Zetta AI, LLC, Sherrill, NY, USA., Lee K; Zetta AI, LLC, Sherrill, NY, USA.; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA., Halageri A; Zetta AI, LLC, Sherrill, NY, USA., Castro M; Zetta AI, LLC, Sherrill, NY, USA., Ih D; Zetta AI, LLC, Sherrill, NY, USA., Gager J; Zetta AI, LLC, Sherrill, NY, USA., Tammam M; Zetta AI, LLC, Sherrill, NY, USA., Dorkenwald S; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.; Computer Science Department, Princeton University, Princeton, NJ, USA., Collman F; Allen Institute for Brain Science, Seattle, WA, USA., Schneider-Mizell C; Allen Institute for Brain Science, Seattle, WA, USA., Brittain D; Allen Institute for Brain Science, Seattle, WA, USA., Jordan CS; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA., Macrina T; Zetta AI, LLC, Sherrill, NY, USA., Dickinson M; California Institute of Technology, Pasadena, CA, USA., Lee WA; Department of Neurobiology, Harvard Medical School, Boston, MA, USA. wei-chung_lee@hms.harvard.edu.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. wei-chung_lee@hms.harvard.edu., Tuthill JC; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA. tuthill@uw.edu.
Jazyk: angličtina
Zdroj: Nature [Nature] 2024 Jul; Vol. 631 (8020), pp. 369-377. Date of Electronic Publication: 2024 Jun 26.
DOI: 10.1038/s41586-024-07600-z
Abstrakt: Animal movement is controlled by motor neurons (MNs), which project out of the central nervous system to activate muscles 1 . MN activity is coordinated by complex premotor networks that facilitate the contribution of individual muscles to many different behaviours 2-6 . Here we use connectomics 7 to analyse the wiring logic of premotor circuits controlling the Drosophila leg and wing. We find that both premotor networks cluster into modules that link MNs innervating muscles with related functions. Within most leg motor modules, the synaptic weights of each premotor neuron are proportional to the size of their target MNs, establishing a circuit basis for hierarchical MN recruitment. By contrast, wing premotor networks lack proportional synaptic connectivity, which may enable more flexible recruitment of wing steering muscles. Through comparison of the architecture of distinct motor control systems within the same animal, we identify common principles of premotor network organization and specializations that reflect the unique biomechanical constraints and evolutionary origins of leg and wing motor control.
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
Externí odkaz: