Social context and drug cues modulate inhibitory control in cocaine addiction: involvement of the STN evidenced through functional MRI.

Autor: Terenzi D; Institut de Neurosciences de la Timone, UMR 7289 CNRS & Aix-Marseille Université, Marseille, France. damiano.TERENZI@univ-amu.fr., Simon N; Institut de Neurosciences de la Timone, UMR 7289 CNRS & Aix-Marseille Université, Marseille, France.; SESSTIM INSERM, IRD & Aix-Marseille Université, AP-HM, Marseille, France., Gachomba MJM; Institut de Neurosciences de la Timone, UMR 7289 CNRS & Aix-Marseille Université, Marseille, France., de Peretti JL; Institut de Neurosciences de la Timone, UMR 7289 CNRS & Aix-Marseille Université, Marseille, France., Nazarian B; Institut de Neurosciences de la Timone, UMR 7289 CNRS & Aix-Marseille Université, Marseille, France., Sein J; Institut de Neurosciences de la Timone, UMR 7289 CNRS & Aix-Marseille Université, Marseille, France., Anton JL; Institut de Neurosciences de la Timone, UMR 7289 CNRS & Aix-Marseille Université, Marseille, France., Grandjean D; Swiss Center for Affective Science and Department of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland., Baunez C; Institut de Neurosciences de la Timone, UMR 7289 CNRS & Aix-Marseille Université, Marseille, France. christelle.baunez@cnrs.fr., Chaminade T; Institut de Neurosciences de la Timone, UMR 7289 CNRS & Aix-Marseille Université, Marseille, France.
Jazyk: angličtina
Zdroj: Molecular psychiatry [Mol Psychiatry] 2024 Dec; Vol. 29 (12), pp. 3742-3751. Date of Electronic Publication: 2024 Jun 26.
DOI: 10.1038/s41380-024-02637-y
Abstrakt: Addictions often develop in a social context, although the influence of social factors did not receive much attention in the neuroscience of addiction. Recent animal studies suggest that peer presence can reduce cocaine intake, an influence potentially mediated, among others, by the subthalamic nucleus (STN). However, there is to date no neurobiological study investigating this mediation in humans. This study investigated the impact of social context and drug cues on brain correlates of inhibitory control in individuals with and without cocaine use disorder (CUD) using functional Magnetic Resonance Imaging (fMRI). Seventeen CUD participants and 17 healthy controls (HC) performed a novel fMRI "Social" Stop-Signal Task (SSST) in the presence or absence of an observer while being exposed to cocaine-related (vs. neutral) cues eliciting craving in drug users. The results showed that CUD participants, while slower at stopping with neutral cues, recovered control level stopping abilities with cocaine cues, while HC did not show any difference. During inhibition (Stop Correct vs Stop Incorrect), activity in the right STN, right inferior frontal gyrus (IFG), and bilateral orbitofrontal cortex (OFC) varied according to the type of cue. Notably, the presence of an observer reversed this effect in most areas for CUD participants. These findings highlight the impact of social context and drug cues on inhibitory control in CUD and the mediation of these effects by the right STN and bilateral OFC, emphasizing the importance of considering the social context in addiction research. They also comfort the STN as a potential addiction treatment target.
Competing Interests: Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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