Gut microbiota signatures of vulnerability to food addiction in mice and humans.

Autor:	Samulėnaitė S; Laboratory of Neuropharmacology-Neurophar, Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain.; Department of Biological Models, Institute of Biochemistry, Life Sciences Center, Vilnius University, Vilnius, Lithuania., García-Blanco A; Laboratory of Neuropharmacology-Neurophar, Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain., Mayneris-Perxachs J; Nutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IdibGi), Girona, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.; Department of Diabetes, Endocrinology and Nutrition, Dr Josep Trueta University Hospital, Girona, Spain., Domingo-Rodríguez L; Laboratory of Neuropharmacology-Neurophar, Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain., Cabana-Domínguez J; Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, (CIBERER), Madrid, Spain.; Institut de Biomedicina de la Universitat de Barcelona, (IBUB), Barcelona, Spain.; Institut de Recerca Sant Joan de Déu (IR-SJD), Esplugues de Llobregat, Barcelona, Spain., Fernàndez-Castillo N; Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, (CIBERER), Madrid, Spain.; Institut de Biomedicina de la Universitat de Barcelona, (IBUB), Barcelona, Spain.; Institut de Recerca Sant Joan de Déu (IR-SJD), Esplugues de Llobregat, Barcelona, Spain., Gago-García E; Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, (CIBERER), Madrid, Spain.; Institut de Biomedicina de la Universitat de Barcelona, (IBUB), Barcelona, Spain.; Institut de Recerca Sant Joan de Déu (IR-SJD), Esplugues de Llobregat, Barcelona, Spain., Pineda-Cirera L; Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, (CIBERER), Madrid, Spain.; Institut de Biomedicina de la Universitat de Barcelona, (IBUB), Barcelona, Spain.; Institut de Recerca Sant Joan de Déu (IR-SJD), Esplugues de Llobregat, Barcelona, Spain., Burokas A; Department of Biological Models, Institute of Biochemistry, Life Sciences Center, Vilnius University, Vilnius, Lithuania., Espinosa-Carrasco J; Centre for Genomic Regulation (CRG), Barcelona, Spain., Arboleya S; APC Microbiome Institute, University College Cork, Cork, Ireland.; Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Villaviciosa, Asturias, Spain., Latorre J; Nutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IdibGi), Girona, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.; Department of Diabetes, Endocrinology and Nutrition, Dr Josep Trueta University Hospital, Girona, Spain., Stanton C; APC Microbiome Institute, University College Cork, Cork, Ireland.; Teagasc Food Research Centre, Moorepark, Fermoy, Co, Cork, Ireland., Hosomi K; Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Ibaraki, Osaka, Japan. (NIBIOHN), Ibaraki, Osaka, Japan., Kunisawa J; Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Ibaraki, Osaka, Japan. (NIBIOHN), Ibaraki, Osaka, Japan., Cormand B; Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, (CIBERER), Madrid, Spain.; Institut de Biomedicina de la Universitat de Barcelona, (IBUB), Barcelona, Spain.; Institut de Recerca Sant Joan de Déu (IR-SJD), Esplugues de Llobregat, Barcelona, Spain., Fernández-Real JM; Nutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IdibGi), Girona, Spain rafael.maldonado@upf.edu jmfreal@idibgi.org elena.martin@upf.edu.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.; Department of Diabetes, Endocrinology and Nutrition, Dr Josep Trueta University Hospital, Girona, Spain.; Department of Medical Sciences, Faculty of Medicine, University of Girona, Girona, Spain., Maldonado R; Laboratory of Neuropharmacology-Neurophar, Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain rafael.maldonado@upf.edu jmfreal@idibgi.org elena.martin@upf.edu.; Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain., Martín-García E; Laboratory of Neuropharmacology-Neurophar, Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain rafael.maldonado@upf.edu jmfreal@idibgi.org elena.martin@upf.edu.; Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.; Departament de Psicobiologia i Metodologia de les Ciències de la Salut, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain.; Institut de Neurociències, Universitat Autònoma de Barcelona, Barcelona, Spain.
Jazyk:	angličtina
Zdroj:	Gut [Gut] 2024 Oct 07; Vol. 73 (11), pp. 1799-1815. Date of Electronic Publication: 2024 Oct 07.
DOI:	10.1136/gutjnl-2023-331445
Abstrakt:	Objective: Food addiction is a multifactorial disorder characterised by a loss of control over food intake that may promote obesity and alter gut microbiota composition. We have investigated the potential involvement of the gut microbiota in the mechanisms underlying food addiction. Design: We used the Yale Food Addiction Scale (YFAS) 2.0 criteria to classify extreme food addiction in mouse and human subpopulations to identify gut microbiota signatures associated with vulnerability to this disorder. Results: Both animal and human cohorts showed important similarities in the gut microbiota signatures linked to food addiction. The signatures suggested possible non-beneficial effects of bacteria belonging to the Proteobacteria phylum and potential protective effects of Actinobacteria against the development of food addiction in both cohorts of humans and mice. A decreased relative abundance of the species Blautia wexlerae was observed in addicted humans and of Blautia genus in addicted mice. Administration of the non-digestible carbohydrates, lactulose and rhamnose, known to favour Blautia growth, led to increased relative abundance of Blautia in mice faeces in parallel with dramatic improvements in food addiction. A similar improvement was revealed after oral administration of Blautia wexlerae as a beneficial microbe. Conclusion: By understanding the crosstalk between this behavioural alteration and gut microbiota, these findings constitute a step forward to future treatments for food addiction and related eating disorders. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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