An ethically guided preclinical device for phenotyping H 2 production in laboratory rodents.
Autor: | Pascal-Moussellard V; University Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, Grenoble, France., Boucher E; University Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, Grenoble, France., Tanguy S; University Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, Grenoble, France., Cinquin P; University Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, Grenoble, France., Barraud PA; University Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, Grenoble, France., Davin C; University Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, Grenoble, France., Salomez-Ihl C; University Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, Grenoble, France., Hannani D; University Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, Grenoble, France., Boucher F; University Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, Grenoble, France., Alcaraz JP; University Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, Grenoble, France. |
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Jazyk: | angličtina |
Zdroj: | Animal models and experimental medicine [Animal Model Exp Med] 2024 Aug; Vol. 7 (4), pp. 553-561. Date of Electronic Publication: 2024 Jun 25. |
DOI: | 10.1002/ame2.12460 |
Abstrakt: | Background: Dihydrogen (H Methods: This study proposes an innovative solution to accurately monitor H Results: HPR in hyperphagic Zucker rats was found to be twice as high as in control Wistar rats, respectively, 2.64 and 1.27 nmol.s -1 per animal. In addition, the ingestion of inulin, a dietary fiber, stimulated H Conclusions: The proposed device coupled with our algorithm enables fine analysis of the metabolic phenotype of laboratory rats or mice with regard to their endogenous H (© 2024 The Author(s). Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences.) |
Databáze: | MEDLINE |
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