PARticular MARks: Histone ADP-ribosylation and the DNA damage response.

Autor: Özdemir C; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA., Purkey LR; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA., Sanchez A; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address: anthony.sanchez@austin.utexas.edu., Miller KM; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA; Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address: kyle.miller@austin.utexas.edu.
Jazyk: angličtina
Zdroj: DNA repair [DNA Repair (Amst)] 2024 Aug; Vol. 140, pp. 103711. Date of Electronic Publication: 2024 Jun 22.
DOI: 10.1016/j.dnarep.2024.103711
Abstrakt: Cellular and molecular responses to DNA damage are highly orchestrated and dynamic, acting to preserve the maintenance and integrity of the genome. Histone proteins bind DNA and organize the genome into chromatin. Post-translational modifications of histones have been shown to play an essential role in orchestrating the chromatin response to DNA damage by regulating the DNA damage response pathway. Among the histone modifications that contribute to this intricate network, histone ADP-ribosylation (ADPr) is emerging as a pivotal component of chromatin-based DNA damage response (DDR) pathways. In this review, we survey how histone ADPr is regulated to promote the DDR and how it impacts chromatin and other histone marks. Recent advancements have revealed histone ADPr effects on chromatin structure and the regulation of DNA repair factor recruitment to DNA lesions. Additionally, we highlight advancements in technology that have enabled the identification and functional validation of histone ADPr in cells and in response to DNA damage. Given the involvement of DNA damage and epigenetic regulation in human diseases including cancer, these findings have clinical implications for histone ADPr, which are also discussed. Overall, this review covers the involvement of histone ADPr in the DDR and highlights potential future investigations aimed at identifying mechanisms governed by histone ADPr that participate in the DDR, human diseases, and their treatments.
Competing Interests: Declaration of Competing Interest We declare that we have no conflicts of interests that need to be disclosed.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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