Glycerides of lauric acid supplementation in the chicken diet enhances the humoral and cellular immune response to infectious bronchitis virus.

Autor: Mellouk A; Adisseo France S.A.S. European Laboratory of Innovation, Science & Expertise (ELISE), Department of R&I in Monogastric Animal Nutrition, 20 rue Prosper Monnet, Saint Fons 69190, France., Michel V; Adisseo France S.A.S. European Laboratory of Innovation, Science & Expertise (ELISE), Department of R&I in Monogastric Animal Nutrition, 20 rue Prosper Monnet, Saint Fons 69190, France., Lemâle O; Adisseo France S.A.S. European Laboratory of Innovation, Science & Expertise (ELISE), Department of R&I in Monogastric Animal Nutrition, 20 rue Prosper Monnet, Saint Fons 69190, France., Goossens T; Adisseo France S.A.S. European Laboratory of Innovation, Science & Expertise (ELISE), Department of R&I in Monogastric Animal Nutrition, 20 rue Prosper Monnet, Saint Fons 69190, France., Consuegra J; Adisseo France S.A.S. European Laboratory of Innovation, Science & Expertise (ELISE), Department of R&I in Monogastric Animal Nutrition, 20 rue Prosper Monnet, Saint Fons 69190, France. Electronic address: jessika.consuegra@adisseo.com.
Jazyk: angličtina
Zdroj: Veterinary immunology and immunopathology [Vet Immunol Immunopathol] 2024 Aug; Vol. 274, pp. 110802. Date of Electronic Publication: 2024 Jun 22.
DOI: 10.1016/j.vetimm.2024.110802
Abstrakt: Controlling pathogenic infections while reducing antibiotic usage is an important challenge during poultry production. In addition to vaccination strategies, several solutions to enhance the immune response against pathogens are evaluated. In this study, we aim to determine the effects of the glycerides of lauric acid (GLA) supplementation in chickens' diets on humoral and cellular immune response pathogenic infections, using an in vivo model of infectious bronchitis virus (IBV). One-day-old Ross 308 broilers were vaccinated with live attenuated IBV and fed diets supplemented with or without GLA at 3 kg/ton. The levels of early (day 7) specific anti-IBV in sera were significantly increased in broilers fed GLA, compared to the control groups (P<0.05), showing a stronger primary humoral response. The secretion levels of main cytokines remained similar in spleens of all the experimental groups. However, the splenocytes from broilers fed GLA showed higher activation and effector abilities when measured by IFN-γ ELISpot in presence of N-261-280 IBV peptide or Concanavalin A (Con A), a pan T lymphocytes mitogen. In response to N-261-280 peptide, GLA group showed a 2-fold increase of spot numbers (P < 0.05) and 3-fold increase of spot surfaces (P < 0.01) compared to the control groups. Similarly, Con A stimulation showed a 2-fold increases in spot surfaces and numbers in the GLA supplemented group compared to the control group (P < 0.01). In summary, GLA supplementation in chicken feed enhances the primary humoral immune response and strengthen the T lymphocytes mediated cellular immune response. These findings demonstrate how GLA can improve chicken resilience against pathogenic challenges by enhancing their immune responses.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: The glycerides of lauric acid are commercialized by Adisseo France SAS. AM, VM and JC are affiliated to Adisseo’s department of research and innovation, TG and OL are affiliated to Adisseo’s HbN BU. The authors declare that their affiliation with the company does not influence the results, conclusions, and analyses reported in this paper. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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