Urticaria and the risk of cancer: a Danish population-based cohort study.

Autor:	Sørensen SBT; Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark., Farkas DK; Department of Clinical Epidemiology, Aarhus University Hospital and Aarhus University, Aarhus, Denmark., Vestergaard C; Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark., Schmidt SAJ; Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Epidemiology, Aarhus University Hospital and Aarhus University, Aarhus, Denmark., Lindahl LM; Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark., Mansfield KE; Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK., Langan SM; Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK., Sørensen HT; Department of Clinical Epidemiology, Aarhus University Hospital and Aarhus University, Aarhus, Denmark.
Jazyk:	angličtina
Zdroj:	The British journal of dermatology [Br J Dermatol] 2024 Oct 17; Vol. 191 (5), pp. 706-712.
DOI:	10.1093/bjd/ljae264
Abstrakt:	Background: Urticaria has been tentatively linked to cancer, but epidemiological evidence supporting this link is sparse and conflicting. We conducted a population-based cohort study using healthcare databases covering the Danish population (January 1980-December 2022). We followed 87 507 people for a median of 10.1 years after their first hospital contact for urticaria. Objectives: To examine associations of a hospital diagnosis of urticaria with incident cancer. Methods: We computed the absolute risk of cancer and standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) standardized to Danish national cancer rates. In a cross-sectional analysis, we examined whether the extent of cancer spread differed between people with vs. without a previous urticaria diagnosis. Results: The overall SIR for all types of cancer was 1.09 (95% CI 1.06-1.11) based on 7788 observed vs. 7161 expected cases. The risk for any cancer was 0.7% (95% CI 0.6-0.7) for the first year of follow-up. Cancer was diagnosed in 588 people with urticaria during the first year of follow-up (SIR 1.49, 95% CI 1.38-1.62) and in 7200 people thereafter (SIR 1.06, 95% CI 1.04-1.09). During the first year of follow-up, we found strong associations with haematological cancers (e.g. non-Hodgkin lymphoma; SIR 2.91, 95% CI 1.92-4.23). Cancer stage was similar in people with vs. without a previous urticaria diagnosis. Conclusions: At the time of urticaria diagnosis, or in the first year afterward, we found a large increase in the risk of cancer. In subsequent years, a persistent 6% increase in risk remained. Diagnostic efforts may partly explain the elevated short-term risk, but occult cancer may promote urticaria, or cancer and urticaria share common risk factors. Competing Interests: Conflicts of interest The Department of Clinical Epidemiology, Aarhus University, receives funding for other studies in the form of institutional research grants to (and administered by) Aarhus University. None of these studies has any relation to the present study. (© The Author(s) 2024. Published by Oxford University Press on behalf of British Association of Dermatologists. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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