Site-Selective Activation and Stereospecific Functionalization of Bis(boronic Esters) Derived from 2-Alkenes: Construction of Propionates and Other 1,2-Difunctional Motifs.

Autor: Xu N; Department of Chemistry, Boston College, Chestnut Hill, MA 02467, USA., Holmgren JL 3rd; Department of Chemistry, Boston College, Chestnut Hill, MA 02467, USA., Morken JP; Department of Chemistry, Boston College, Chestnut Hill, MA 02467, USA.
Jazyk: angličtina
Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Sep 23; Vol. 63 (39), pp. e202408436. Date of Electronic Publication: 2024 Aug 13.
DOI: 10.1002/anie.202408436
Abstrakt: Non-directed regioselective activation of bis(boronic esters), followed by functionalization, is reported. A bulky activator is shown to selectively activate the less hindered boronic ester enabling it to undergo stereospecific cross-coupling to a variety of electrophiles. This steric-based regioselectivity provides a simple and efficient method to prepare highly functionalized, enantiomerically enriched products starting from simple alkenes.
(© 2024 Wiley-VCH GmbH.)
Databáze: MEDLINE
Externí odkaz: