Gold Trifluoromethyl Complexes as Efficient Regioselective Catalysts in Alkyne Hydration.

Autor: Ruiz-Almoguera D; Institute of Advanced Materials (INAM), Universitat Jaume I, Avda. Sos Baynat s/n, 12006, Castellón, Spain., Ventura-Espinosa D; Institute of Advanced Materials (INAM), Universitat Jaume I, Avda. Sos Baynat s/n, 12006, Castellón, Spain., Pérez-Bitrián A; Instituto de Síntesis Química y Catálisis Homogénea (iSQCH), CSIC-Universidad de Zaragoza, C/Pedro Cerbuna 12, 50009, Zaragoza, Spain.; Current address: Institut für Chemie, Humboldt-Universität zu Berlin, Brook-Taylor-Straße 2, 12489, Berlin, Germany., Martín A; Instituto de Síntesis Química y Catálisis Homogénea (iSQCH), CSIC-Universidad de Zaragoza, C/Pedro Cerbuna 12, 50009, Zaragoza, Spain., Mata JA; Institute of Advanced Materials (INAM), Universitat Jaume I, Avda. Sos Baynat s/n, 12006, Castellón, Spain., Baya M; Instituto de Síntesis Química y Catálisis Homogénea (iSQCH), CSIC-Universidad de Zaragoza, C/Pedro Cerbuna 12, 50009, Zaragoza, Spain.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Sep 16; Vol. 30 (52), pp. e202401753. Date of Electronic Publication: 2024 Sep 09.
DOI: 10.1002/chem.202401753
Abstrakt: Gold(III) complexes containing trifluoromethyl ligands are efficient catalysts in the hydration of alkynes, operating at low catalyst loadings, without additives, using environmentally friendly solvents and at mild conditions (60 °C). Hydration of terminal and internal alkynes provides the corresponding ketones in quantitative yields without special precautions as dry solvents or inert atmospheres. Remarkably, hydration of asymmetric internal alkynes proceeds with moderate to notable regioselectivities, providing mixtures of the two possible isomers with ratios up to 90 : 10.
(© 2024 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.)
Databáze: MEDLINE
Externí odkaz: