A narrative review on the mechanism of natural flavonoids in improving glucolipid metabolism disorders.

Autor: Niu W; Guangdong Metabolic Diseases Research Centre of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Guangdong Provincial TCM Key Laboratory for Metabolic Diseases, Guangzhou, China., Feng Y; Guangdong Metabolic Diseases Research Centre of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Guangdong Provincial TCM Key Laboratory for Metabolic Diseases, Guangzhou, China., Peng M; Guangdong Metabolic Diseases Research Centre of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Guangdong Provincial TCM Key Laboratory for Metabolic Diseases, Guangzhou, China., Cai J; Guangdong Metabolic Diseases Research Centre of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, China.; Guangdong Provincial TCM Key Laboratory for Metabolic Diseases, Guangzhou, China.
Jazyk: angličtina
Zdroj: Phytotherapy research : PTR [Phytother Res] 2024 Aug; Vol. 38 (8), pp. 4202-4229. Date of Electronic Publication: 2024 Jun 26.
DOI: 10.1002/ptr.8276
Abstrakt: Glucolipid metabolism disorder (GLMD) is a complex chronic disease characterized by glucose and lipid metabolism disorders with a complex and diverse etiology and rapidly increasing incidence. Many studies have identified the role of flavonoids in ameliorating GLMD, with mechanisms related to peroxisome proliferator-activated receptors, nuclear factor kappa-B, AMP-activated protein kinase, nuclear factor (erythroid-derived 2)-like 2, glucose transporter type 4, and phosphatidylinositol-3-kinase/protein kinase B pathway. However, a comprehensive summary of the flavonoid effects on GLMD is lacking. This study reviewed the roles and mechanisms of natural flavonoids with different structures in the treatment of GLMD reported globally in the past 5 years and provides a reference for developing flavonoids as drugs for treating GLMD.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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