Helminth infection induces a distinct subset of CD101 hi lung tissue-infiltrating eosinophils that are differentially regulated by type 2 cytokines.

Autor: Noble SL; Malaghan Institute of Medical Research, Wellington, New Zealand.; Department of Medicine, University of Otago, Wellington, New Zealand., Vacca F; Malaghan Institute of Medical Research, Wellington, New Zealand., Hilligan KL; Malaghan Institute of Medical Research, Wellington, New Zealand., Mules TC; Malaghan Institute of Medical Research, Wellington, New Zealand.; Department of Medicine, University of Otago, Wellington, New Zealand.; Te Whatu Ora, Capital Coast and Hutt Valley, Wellington, New Zealand., Le Gros G; Malaghan Institute of Medical Research, Wellington, New Zealand., Inns S; Department of Medicine, University of Otago, Wellington, New Zealand.; Te Whatu Ora, Capital Coast and Hutt Valley, Wellington, New Zealand.
Jazyk: angličtina
Zdroj: Immunology and cell biology [Immunol Cell Biol] 2024 Sep; Vol. 102 (8), pp. 734-746. Date of Electronic Publication: 2024 Jun 26.
DOI: 10.1111/imcb.12796
Abstrakt: Eosinophils play divergent roles in health and disease, contributing to both immunoregulatory and proinflammatory responses. Helminth infection is strongly associated with eosinophilia and the induction of the type 2 cytokines interleukin (IL)-5, IL-4 and IL-13. This study aimed to elucidate the heterogeneity of pulmonary eosinophils in response to helminth infection and the roles of IL-5, IL-4 and IL-13 in driving pulmonary eosinophil responses. Using the murine helminth model Nippostrongylus brasiliensis (Nb), we characterize a subtype of eosinophils, defined by high expression of CD101, that is induced in the lungs of Nb-infected mice and are phenotypically distinct from lung eosinophils that express low levels of CD101. Strikingly, we show that the two eosinophil subtypes have distinct anatomical localization within the lung: CD101 low eosinophils are predominantly localized in the lung vasculature, whereas Nb-induced CD101 hi eosinophils are predominantly localized in the extravascular lung niche. We show that CD101 hi eosinophils are also induced across other models of pulmonary infection and inflammation, including a nonlung-migrating helminth infection, house dust mite-induced allergic inflammation and influenza infection. Furthermore, we demonstrate that the induction of CD101 hi tissue eosinophils is independent of IL-5 and IL-4 signaling, but is dependent on intact IL-13 signaling. These results suggest that IL-13 produced during helminth infection and other disease states promotes a pulmonary tissue-infiltrating program in eosinophils defined by high expression of CD101.
(© 2024 The Author(s). Immunology & Cell Biology published by John Wiley & Sons Australia, Ltd on behalf of the Australian and New Zealand Society for Immunology, Inc.)
Databáze: MEDLINE
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