Understanding maternal sepsis risk factors and bacterial etiology: A case control study protocol.

Autor: Thompson K; The George Institute for Global Health, University of New South Wales, Sydney, Australia.; Nepean Blue Mountains Local Health District, Kingswood, Australia., Thanh DP; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Hirst JE; The George Institute for Global Health, Imperial College London, London, United Kingdom., Woodward M; The George Institute for Global Health, University of New South Wales, Sydney, Australia.; The George Institute for Global Health, Imperial College London, London, United Kingdom., Thanh HP; Tu Du Hospital, Ho Chi Minh City, Vietnam., Lien HTT; Tu Du Hospital, Ho Chi Minh City, Vietnam., Tuan KT; Tu Du Hospital, Ho Chi Minh City, Vietnam., Thanh BL; Tu Du Hospital, Ho Chi Minh City, Vietnam., Kestelyn E; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Trong TD; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Harris K; The George Institute for Global Health, University of New South Wales, Sydney, Australia., My LNT; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Minh HVT; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Thanh TH; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Le Quang T; Tu Du Hospital, Ho Chi Minh City, Vietnam., Thwaites L; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Jun 26; Vol. 19 (6), pp. e0305411. Date of Electronic Publication: 2024 Jun 26 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0305411
Abstrakt: Introduction: Maternal disorders are the third leading cause of sepsis globally, accounting for 5.7 million (12%) cases in 2017. There are increasing concerns about the emergence of antimicrobial resistance (AMR) in bacteria commonly causing maternal sepsis. Our aim is to describe the protocol for a clinical and microbiology laboratory study to understand risk factors for and the bacterial etiology of maternal sepsis in a tertiary Obstetrics and Gynaecology Hospital.
Methods: This case-control study aims to recruit 100 cases and 200 controls at Tu Du Hospital in Ho Chi Minh City, Vietnam, which had approximately 55,000 births in 2022. Women aged ≥ 18 years and ≥ 28 weeks gestation having a singleton birth will be eligible for inclusion as cases or controls, unless they have an uncomplicated localised or chronic infection, or an infection with SARS-CoV-2. Cases will include pregnant or recently pregnant women with sepsis recognised between the onset of labour and/or time of delivery/cessation of pregnancy for up to 42 days post-partum. Sepsis will be defined as suspected or confirmed infection with an obstetrically modified Sequential Organ Failure Assessment score of ≥ 2, treatment with intravenous antimicrobials and requested cultures of any bodily fluid. Controls will be matched by age, location, parity, mode of delivery and gestational age. Primary and secondary outcomes are risk factors associated with the development of maternal sepsis, the frequency of adverse outcomes due to maternal sepsis, bacterial etiology and AMR profiles of cases and controls.
Discussion: This study will improve understanding of the epidemiology and clinical implications of maternal sepsis management including the presence of AMR in women giving birth in Vietnam. It will help us to determine whether women in this setting are receiving optimal care and to identify opportunities for improvement.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Thompson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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