Impact of rural location on receipt of standard of care treatment and survival for locally advanced bladder cancer in Louisiana.

Autor: Escott M; School of Medicine, LSU Health Science Center, New Orleans, Louisiana, USA.; Department of Urology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Yi Y; Louisiana Tumor Registry and Epidemiology, New Orleans, Louisiana, USA.; School of Public Health, LSU Health Science Center, New Orleans, Louisiana, USA., Foret A; School of Medicine, LSU Health Science Center, New Orleans, Louisiana, USA., Li T; Louisiana Tumor Registry and Epidemiology, New Orleans, Louisiana, USA.; School of Public Health, LSU Health Science Center, New Orleans, Louisiana, USA., Hsieh MC; Louisiana Tumor Registry and Epidemiology, New Orleans, Louisiana, USA.; School of Public Health, LSU Health Science Center, New Orleans, Louisiana, USA., Delacroix SE Jr; Department of Urology, LSU Health Science Center, New Orleans, Louisiana, USA., Wu XC; Louisiana Tumor Registry and Epidemiology, New Orleans, Louisiana, USA.; School of Public Health, LSU Health Science Center, New Orleans, Louisiana, USA., Westerman ME; Department of Urology, LSU Health Science Center, New Orleans, Louisiana, USA.
Jazyk: angličtina
Zdroj: Cancer medicine [Cancer Med] 2024 Jun; Vol. 13 (12), pp. e7301.
DOI: 10.1002/cam4.7301
Abstrakt: Objective: We aim to determine the effect of region of residence (urban vs. rural) on the odds of receiving standard of care treatment for locally advanced BCa in Louisiana and its impact on survival outcomes.
Methods: Using the Louisiana Tumor Registry, we identified American Joint Committee on Cancer (AJCC) stage II or III, BCa diagnoses in Louisiana residents between 2010 and 2020. Treatment received was classified as standard or non-standard of care according to American Urological Association (AUA) guidelines and location of residence was determined using Rural Urban Commuting Area-Tract-level 2010 (RUCA). Multivariable logistic regression analyses and multivariate cox proportional hazard analyses were performed.
Results: Of 983 eligible patients, 85.6% (841/983) lived in urban areas. Overall, only 37.5% received standard-of-care (SOC) for the definitive management of locally advanced bladder cancer. Individuals living in rural areas (OR 0.53, 95% CI: 0.31-0.91, p = 0.02) were less likely to receive standard of care treatment. Both rural residence and receipt of non-standard of care therapy were associated with an increased risk of bladder cancer-specific (adj HR 1.53, 95% CI: 1.09-2.14, p = 0.01 and adj HR: 1.85, 95% CI: 1.43-2.39, <0.0001) and overall mortality (adj HR: 1.28, 95% CI: 1.01-1.61, p = 0.04 and adj HR: 1.73 95% CI: 1.44-2.07, p < 0.0001).
Conclusions: Most patients with locally advanced bladder cancer in Louisiana do not receive SOC therapy. Individuals living in rural locations are more likely to receive non-standard of care therapy than individuals in urban areas. Nonstandard of care treatment and rural residence are both associated with worse survival outcomes for Louisiana residents with locally advanced bladder cancer.
(© 2024 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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