Rab GTPases, Active Members in Antigen-Presenting Cells, and T Lymphocytes.

Autor: Moreno-Corona NC; Laboratory of Human Lymphohematopoiesis, Imagine Institute, INSERM UMR 1163, Université de Paris, Paris, France., de León-Bautista MP; Escuela de Medicina, Universidad Vasco de Quiroga, Morelia, Mexico.; Human Health, Laboratorio de Enfermedades Infecciosas y Genómica (INEX LAB), Morelia, Mexico., León-Juárez M; Laboratorio de Virología Perinatal y Diseño Molecular de Antígenos y Biomarcadores, Departamento de Inmunobioquimica, Instituto Nacional de Perinatología, Ciudad de México, Mexico., Hernández-Flores A; Instituto de Salud, Universidad de la Sierra Sur, Miahuatlán de Porfirio Díaz, Mexico., Barragán-Gálvez JC; División de Ciencias Naturales y Exactas, Departamento de Farmacia, Universidad de Guanajuato, Guanajuato, Mexico., López-Ortega O; Université Paris Cité, INSERM UMR-S1151, CNRS UMR-S8253, Institute Necker Enfants Malades, Paris, France.
Jazyk: angličtina
Zdroj: Traffic (Copenhagen, Denmark) [Traffic] 2024 Jun; Vol. 25 (6), pp. e12950.
DOI: 10.1111/tra.12950
Abstrakt: Processes such as cell migration, phagocytosis, endocytosis, and exocytosis refer to the intense exchange of information between the internal and external environment in the cells, known as vesicular trafficking. In eukaryotic cells, these essential cellular crosstalks are controlled by Rab GTPases proteins through diverse adaptor proteins like SNAREs complex, coat proteins, phospholipids, kinases, phosphatases, molecular motors, actin, or tubulin cytoskeleton, among others, all necessary for appropriate mobilization of vesicles and distribution of molecules. Considering these molecular events, Rab GTPases are critical components in specific biological processes of immune cells, and many reports refer primarily to macrophages; therefore, in this review, we address specific functions in immune cells, concretely in the mechanism by which the GTPase contributes in dendritic cells (DCs) and, T/B lymphocytes.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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