A predictive study of genes related to lactic acid metabolism in cervical carcinoma.

Autor: Zou K; Department of Gynecology, Xiangya Hospital, Central South University, Changsha, Hunan, China., Ou J; Department of Gynecology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jazyk: angličtina
Zdroj: The journal of obstetrics and gynaecology research [J Obstet Gynaecol Res] 2024 Sep; Vol. 50 (9), pp. 1552-1565. Date of Electronic Publication: 2024 Jun 25.
DOI: 10.1111/jog.15994
Abstrakt: Objectives: Lactic acid metabolism, a hallmark of carcinogenesis, may play potential roles in cervical carcinoma, assisting the prognosis prediction.
Materials and Methods: A regression analysis was conducted to identify the ones with the most frequent variation in mutations and CNV changes in lactate metabolism-related (L-related) genes, after which a prognostic nomogram was built based on selected genes and clinical features by machine learning methods.
Results: EGLN1, IL1, IL12RB1, ENO1, and 10 other genes had the most frequent changes and prognostic differences in overall survival (OS). The lactated associated risk (LAR) score model can distinguish the patients in OS (p = 0.046, HR = 101.9, 95%CI 1.1-9447.6), and together with clinical features has a higher AUC (AUC = 0.839). Furthermore, CD8 + T, activated CD4 + memory T and resting mast cells were significantly negatively associated with the LAR score.
Conclusions: Lactic acid metabolism is closely related to the prognosis of cervical carcinoma, where the immune microenvironment may play an important role.
(© 2024 Japan Society of Obstetrics and Gynecology.)
Databáze: MEDLINE
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