Correlation between depression scores and serum NF-ĸB/NLRP3 axis, biotinidase, and HMGB1 after treatment with isotretinoin in patients with acne vulgaris.
Autor: | Binsaleh AY; Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia., Ali LS; Department of Basic Medical Science, Faculty of Dentistry, Al-Ahliyya Amman University, Amman, Jordan.; Physiology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Bahaa MM; Pharmacy Practice Department, Faculty of Pharmacy, Horus University, New Damietta, Egypt., Elmasry TA; Pharmacology and Toxicology Department, Faculty of Pharmacy, Tanta University, Tanta, Al-Gharbia, Egypt., Negm WA; Pharmacognosy Department, Faculty of Pharmacy, Tanta University, Tanta, Al-Gharbia, Egypt., Hamouda AO; Department of Biochemistry and Pharmacology, Faculty of Pharmacy, Horus University, New Damietta, Egypt., Salahuddin MM; Department of Biochemistry and Pharmacology, Faculty of Pharmacy, Horus University, New Damietta, Egypt., Wahsh E; Pharmacology and Toxicology Department, Faculty of Pharmacy, Sinai University, Arish, Egypt., El-Samongy MA; Dermatology Department, Faculty of Medicine, Tanta University, Tanta, Al-Gharbia, Egypt., Alsubaie N; Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia., El-Khateeb E; Clinical Pharmacy Department, Faculty of Pharmacy, Tanta University, Tanta, Al-Gharbia, Egypt., Yasser M; Department of Pharmaceutics, Faculty of Pharmacy, Port Said University, Port Said, Egypt.; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Horus University, New Damietta, Egypt., Eltantawy N; Pharmacy Practice Department, Faculty of Pharmacy, Heliopolis University, Cairo 11757, Egypt. |
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Jazyk: | angličtina |
Zdroj: | Journal of cosmetic dermatology [J Cosmet Dermatol] 2024 Oct; Vol. 23 (10), pp. 3409-3417. Date of Electronic Publication: 2024 Jun 24. |
DOI: | 10.1111/jocd.16433 |
Abstrakt: | Background: Acne vulgaris (AV) is an inflammatory skin disorder leading to scars and discomfort, its intensity has major psychological consequences such as depression. Aim: To investigate the effect of isotretinoin (ISO) on NF-κB/NLRP3, biotinidase, and HMGB and correlation with depression. Patients and Methods: This was a case-control study that involved two groups. Group 1 is 20 healthy control, and group 2 is 20 patients diagnosed with AV according to Global Acne Grading System (GAGS) and received 20 mg ISO for 2 months. Before and after therapy, the Hamilton Depression Rating Scale (HDRS) was applied to assess each participant's level of depression. Nuclear factor kappa B (NF-ĸB), biotinidase, high mobility group box protein (HMGB1), nucleotide-binding domain, leucine-rich-containing family, and pyrin domain-containing-3 (NLRP-3) were measured in serum samples. Results: There was no significant difference in all measured markers of healthy group before and after 2 months. Regarding group 2, there was a statistically significant decrease in all measured markers after 2 months of treatment and significant correlations between GAGS, NF-ĸB, HMGB1, NLRP3, biotinidase, and depression score. Conclusion: Increased GAGS, HMGB1, NLRP3, and biotinidase were associated with depression severity in AV patients and ISO treatment significantly reduced these parameters and reduced depressive symptoms. (© 2024 The Author(s). Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.) |
Databáze: | MEDLINE |
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