OPTImal PHARMacological therapy for patients with heart failure: Rationale and design of the OPTIPHARM-HF registry.

Autor: Inciardi RM; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Vaduganathan M; Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, USA., Lombardi CM; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Gussago C; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Agostoni P; Centro Cardiologico Monzino, IRCCS, Milan, Italy.; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy., Ameri P; Cardiology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.; Department of Internal Medicine, University of Genoa, Genoa, Italy., Aspromonte N; Department of Cardiovascular ad Thoracic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy., Calò L; Division of Cardiology, Policlinico Casilino, Rome, Italy., Cameli M; Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy., Carluccio E; Cardiology and Cardiovascular Pathophysiology, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy., Carugo S; Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico and Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy., Cipriani M; Clinical Cardiology and Heart Failure Unit, Mediterranean Institute for Transplantation and Advanced Specialized Therapies ISMETT, Palermo, Italy., De Caterina R; Cardiology Division, Cardiothoracic and Vascular Department, Pisa University Hospital, Pisa, Italy.; Department of Surgical, Medical and Molecular Pathology and of Critical Sciences, University of Pisa, Pisa, Italy., De Ferrari GM; Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza Hospital, Turin, Italy.; Department of Medical Sciences, University of Turin, Turin, Italy., Emdin M; Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy.; Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna, Pisa, Italy., Fornaro A; Cardiology Unit, Careggi University Hospital, Florence, Italy., Guazzi M; Cardiology Division, San Paolo Hospital, Milan, Italy.; Department of Biological Sciences, University of Milan School of Medicine, Milan, Italy., Iacoviello M; Cardiology Unit, University Hospital Policlinico Riuniti, Foggia, Italy.; Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy., Imazio M; Department of Medicine (DMED), University of Udine, and Cardiothoracic Department, University Hospital Santa Maria della Misericordia, ASUFC, Udine, Italy., La Rovere MT; Department of Cardiology, Istituti Clinici Scientifici Maugeri IRCCS, Montescano, Italy., Leonardi S; Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Maccallini M; Humanitas Clinical and Research Hospital IRCCS, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Masarone D; Heart Failure Unit, Department of Cardiology, AORN dei Colli-Monaldi Hospital, Naples, Italy., Moschini L; Division of Cardiology, Ospedale Oglio Po, ASST Cremona, Cremona, Italy., Palazzuoli A; Cardiovascular Diseases Unit, Cardiothoracic and Vascular Department, Le Scotte Hospital, University of Siena, Siena, Italy., Patti G; Division of Cardiology, AOU Maggiore della Carità, Novara, Italy.; Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy., Pedretti RFE; Unit of Cardiology, Cardiovascular Department, IRCCS MultiMedica, Sesto San Giovanni, Milan, Italy.; University of Milano - Bicocca, School of Medicine and Surgery, Milan, Italy., Perrone Filardi P; Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy., Piepoli MF; Clinical Cardiology, IRCCS Policlinicco San Donato, San Donato Milanese, Milan, Italy.; Department of Biomedical Science for Health, University of Milan, Milan, Italy., Potena L; Heart Failure and Transplant Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy., Salzano A; Cardiology Unit, AORN Antonio Cardarelli, Naples, Italy., Sciacqua A; Geriatrics Division. AOU R.Dulbecco, Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy., Senni M; Cardiology Unit, Cardiovascular Department, ASST Papa Giovanni XXIII, Bergamo, Italy., Sinagra G; Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste, Trieste, Italy., Specchia C; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Taddei S; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Vizza D; Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy., Savarese G; Division of Cardiology, Department of Medicine, Karolinska Institutet, and Heart and Vascular and Neuro Theme, Karolinska University Hospital, Stockholm, Sweden., Rosano G; Chair of Pharmacology, University San Raffaele, Rome, Italy.; Cardiology, San Raffaele Cassino Hospital, Cassino, Italy.; Cardiovascular CAG, St George's University Hospital, London, UK., Volterrani M; Department of Exercise Science and Medicine, San Raffaele Open University of Rome, Italy.; Cardiopulmonary Department, IRCCS San Raffaele Roma, Rome, Italy., Metra M; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Jazyk: angličtina
Zdroj: European journal of heart failure [Eur J Heart Fail] 2024 Aug; Vol. 26 (8), pp. 1707-1714. Date of Electronic Publication: 2024 Jun 23.
DOI: 10.1002/ejhf.3260
Abstrakt: Aims: Patients with heart failure (HF) remain often undertreated for multiple reasons, including treatment inertia, contraindications, and intolerance. The OPTIimal PHARMacological therapy for patients with Heart Failure (OPTIPHARM-HF) registry is designed to evaluate the prevalence of evidence-based medical treatment prescription and titration, as well as the causes of its underuse, in a broad real-world population of consecutive patients with HF across the whole ejection fraction spectrum and among different clinical phenotypes.
Methods: The OPTIPHARM-HF registry (NCT06192524) is a prospective, multicenter, observational, national study of adult patients with symptomatic HF, as defined by current international guidelines, regardless of ejection fraction. Both outpatients and inpatients with chronic and acute decompensated HF will be recruited. The study will enroll up to 2500 patients with chronic HF at approximately 35 Italian HF centres. Patients will be followed for a maximum duration of 24 months. The primary objective of the OPTIPHARM-HF registry is to assess prescription and adherence to evidence-based guideline-directed medical therapy (GDMT) in patients with HF. The primary outcome is to describe the prevalence of GDMT use according to target guideline recommendation. Secondary objectives include implementation of comorbidity treatment, evaluation of sequence of treatment introduction and up-titration, description of GDMT implementation in the specific HF population, main causes of GDMT underuse, and assessment of cumulative rate of cardiovascular events.
Conclusion: The OPTIPHARM-HF registry will provide important implications for improving patient care and adoption of recommended medical therapy into clinical practice among HF patients.
(© 2024 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)
Databáze: MEDLINE
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