The true extent of eosinophil involvement in disease is unrecognized: the secret life of dead eosinophils.

Autor:	Leiferman KM; Department of Dermatology, University of Utah Health, Helix Building, 1st Floor South, 30 North Mario Capecchi Drive, Salt Lake City, UT, 84112United States., Gleich GJ; Department of Dermatology, University of Utah Health, Helix Building, 1st Floor South, 30 North Mario Capecchi Drive, Salt Lake City, UT, 84112United States.; Department of Internal Medicine, University of Utah Health, Helix Building, 3rd Floor North, 30 North Mario Capechhi Drive, Salt Lake City, UT, 84112United States.
Jazyk:	angličtina
Zdroj:	Journal of leukocyte biology [J Leukoc Biol] 2024 Jul 25; Vol. 116 (2), pp. 271-287.
DOI:	10.1093/jleuko/qiae052
Abstrakt:	Eosinophil-mediated pathophysiology is tissue destructive and tissue altering with proinflammatory, prothrombotic, and profibrotic effects. The distinctive morphology of an eosinophil reveals a cytoplasm chockfull of unique granules, and the granule proteins have numerous toxic effects on cells, tissues, and organs. Eosinophils are not found in most human tissues, and eosinophil involvement in diseased tissues generally is identified by cell infiltration on histopathologic examination. However, eosinophils characteristically lose their structural integrity and deposit granules and granule proteins at sites of inflammation. Hence, their participation in tissue damage may be underrecognized or entirely overlooked. The eosinophil major basic protein 1 is a toxic granule protein and, when deposited, persists in tissues. Major basic protein 1 deposition can be regarded as a footprint of eosinophil activity. Analyses of numerous eosinophil-related diseases have demonstrated clear-cut evidence of major basic protein 1 deposition in affected tissues where eosinophils were not recognized by hematoxylin and eosin tissue staining and light microscopy. Eosinophil granule protein deposition, as exemplified by localization of major basic protein 1, especially when disproportionately greater than cellular infiltration, emerges as a biomarker of hidden eosinophil-related pathophysiology. Consequently, current assessments of recognized eosinophils may vastly underestimate their role in disease. Competing Interests: Conflict of interest statement. None declared. (© The Author(s) 2024. Published by Oxford University Press on behalf of Society for Leukocyte Biology.)
Databáze:	MEDLINE
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