Randomized split-mouth clinical trial comparing osteoblastic activity and osteogenic potential of autogenous particle harvesting during implant surgery without irrigation and with irrigation.

Autor: Camacho-Alonso F; Department of Oral Surgery, University of Murcia, Murcia, Spain., Mercado-Díaz AM; Department of Oral Surgery, University of Murcia, Murcia, Spain., Rivas-Ballester R; Department of Oral Surgery, University of Murcia, Murcia, Spain., Bernabeu-Mira JC; Oral Surgery Unit, Department of Stomatology, University of Valencia, Valencia, Spain., Peñarrocha-Oltra D; Oral Surgery Unit, Department of Stomatology, University of Valencia, Valencia, Spain., Del Rosario Tudela-Mulero M; Scientific and Technical Research Area (ACTI), University of Murcia, Murcia, Spain.
Jazyk: angličtina
Zdroj: Clinical implant dentistry and related research [Clin Implant Dent Relat Res] 2024 Aug; Vol. 26 (4), pp. 795-808. Date of Electronic Publication: 2024 Jun 23.
DOI: 10.1111/cid.13355
Abstrakt: Objective: To compare the osteoblastic activity and osteogenic potential of autogenous particle harvesting during implant surgery using low-speed drilling without irrigation and high-speed drilling with irrigation.
Materials and Methods: Thirty patients with bilateral missing teeth of 3.6 and 4.6 were randomized into two groups (Group 1: low-speed drilling without irrigation and Group 2: high-speed drilling with irrigation) and 60 single dental implants were placed. The temperature at the tip of each drill was recorded and the harvested bone was weighed; particle size and Ca and P levels were also analyzed. After osteoblast culture, cell viability, cell cycle assay, cell migration, vascular endothelial growth factor (VEGF) concentration, and mineralized nodule formation were assessed.
Results: Although the temperature of the drills was slightly higher in Group 1, no statistically significant differences were observed (p ≤ 0.05); however, the amount of harvested bone was higher (p < 0.001) and the size of the particles was higher (p = 0.019). In relation to osteoblastic activity and osteogenic potential, higher cell proliferation, higher number of cells in G2/M and S phases, higher cell migration capacity, higher VEGF concentration, and higher amount of mineralized nodule formation were observed in Group 1.
Conclusions: Low-speed drilling without irrigation does not result in a significant increase in bone temperature compared to conventional drilling. However, a greater amount of bone is obtained; in addition, osteoblastic activity and osteogenic potential are higher with this technique, but further clinical studies are necessary.
(© 2024 The Author(s). Clinical Implant Dentistry and Related Research published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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