Increased [ 18 F]FDG uptake in the infarcted myocardial area displayed by combined PET/CMR correlates with snRNA-seq-detected inflammatory cell invasion.

Autor: Lukovic D; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Gyöngyösi M; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria. mariann.gyongyosi@meduniwien.ac.at., Pavo IJ; Division of Pediatric Cardiology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria., Mester-Tonczar J; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Einzinger P; Institute of Information Systems Engineering, Research Unit of Information and Software Engineering, Vienna University of Technology, 1040, Vienna, Austria., Zlabinger K; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Kastner N; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Spannbauer A; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Traxler D; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Pavo N; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Goliasch G; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Pils D; Division of General Surgery, Department of Surgery, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria., Jakab A; Center for MR-Research, University Children's Hospital Zurich, Zurich, Switzerland., Szankai Z; Department of Neurology, Kantonsspital Aarau, Aarau, Switzerland., Michel-Behnke I; Division of Pediatric Cardiology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria., Zhang L; Cardiovascular Research Unit, Department of Population Health, Luxembourg Institute of Health, Strassen, Luxembourg., Devaux Y; Cardiovascular Research Unit, Department of Population Health, Luxembourg Institute of Health, Strassen, Luxembourg., Graf S; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Beitzke D; Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria., Winkler J; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.
Jazyk: angličtina
Zdroj: Basic research in cardiology [Basic Res Cardiol] 2024 Oct; Vol. 119 (5), pp. 807-829. Date of Electronic Publication: 2024 Jun 26.
DOI: 10.1007/s00395-024-01064-y
Abstrakt: Combined [ 18 F]FDG PET-cardiac MRI imaging (PET/CMR) is a useful tool to assess myocardial viability and cardiac function in patients with acute myocardial infarction (AMI). Here, we evaluated the prognostic value of PET/CMR in a porcine closed-chest reperfused AMI (rAMI) model. Late gadolinium enhancement by PET/CMR imaging displayed tracer uptake defect at the infarction site by 3 days after the rAMI in the majority of the animals (group Match, n = 28). Increased [ 18 F]FDG uptake at the infarcted area (metabolism/contractility mismatch) with reduced tracer uptake in the remote viable myocardium (group Mismatch, n = 12) 3 days after rAMI was observed in the animals with larger infarct size and worse left ventricular ejection fraction (LVEF) (34 ± 8.7 vs 42.0 ± 5.2%), with lower LVEF also at the 1-month follow-up (35.8 ± 9.5 vs 43.0 ± 6.3%). Transcriptome analyses by bulk and single-nuclei RNA sequencing of the infarcted myocardium and border zones (n = 3 of each group, and 3 sham-operated controls) revealed a strong inflammatory response with infiltration of monocytes and macrophages in the infarcted and border areas in Mismatch animals. Our data indicate a high prognostic relevance of combined PET/MRI in the subacute phase of rAMI for subsequent impairment of heart function and underline the adverse effects of an excessive activation of the innate immune system in the initial phase after rAMI.
(© 2024. The Author(s).)
Databáze: MEDLINE
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