| Autor: |
Ignácio FS; Department of Veterinary Surgery and Animal Surgery, School of Veterinary Medicine and Animal Science (FMVZ), Sao Paulo State University (UNESP), Botucatu 18618-681, SP, Brazil., Garcia LV; Department of Veterinary Medicine, University Center of the Integrated Faculties of Ourinhos (Unifio), Ourinhos 19909-100, SP, Brazil., de Souza GG; Department of Veterinary Medicine, University Center of the Integrated Faculties of Ourinhos (Unifio), Ourinhos 19909-100, SP, Brazil., Amatti LZ; Department of Veterinary Medicine, University Center of the Integrated Faculties of Ourinhos (Unifio), Ourinhos 19909-100, SP, Brazil., de Barros LD; Laboratory of Veterinary Parasitology and Parasitic Diseases, Department of Veterinary Medicine, Federal University of Lavras, Lavras 37203-202, MG, Brazil., Bergfelt DR; Department of Biomedical Science, Ross University School of Veterinary Medicine, Basseterre P.O. Box 334, Saint Kitts and Nevis., Camargo GS; Department of Veterinary Surgery and Animal Surgery, School of Veterinary Medicine and Animal Science (FMVZ), Sao Paulo State University (UNESP), Botucatu 18618-681, SP, Brazil., de Meira C; Department of Veterinary Surgery and Animal Surgery, School of Veterinary Medicine and Animal Science (FMVZ), Sao Paulo State University (UNESP), Botucatu 18618-681, SP, Brazil., de Almeida BFM; Department of Veterinary Medicine, University Center of the Integrated Faculties of Ourinhos (Unifio), Ourinhos 19909-100, SP, Brazil.; Departament of Clinics, Surgery and Animal Reproduction, Faculty of Veterinary Medicine of Araçatuba (FMVA), São Paulo State University (UNESP), Araçatuba 16050-680, SP, Brazil. |
| Abstrakt: |
Non-steroidal anti-inflammatory drugs (NSAIDs) represent one of the most commonly used classes of drugs in both human and veterinary medicine. However, many clinical side effects have been observed, especially when treatment has been prolonged. While the anti-inflammatory efficacy and safety of repeated administration of firocoxib (Previcox ® ), which is a selective NSAID COX-2 inhibitor, has been evaluated for short-term use (one to fourteen days), its clinical relevance for longer-term use is not known. As a preliminary study, healthy, adult male and female horses (n = 7) were treated with firocoxib for 40 days concomitant with the collection of blood samples encompassing treatment to assess hematological and biochemical endpoints. Daily oral administration of firocoxib was performed with one 57 mg tablet/animal (0.11-0.14 mg/kg), which was crushed and mixed with feed. Blood samples were collected one day before treatment (D0 or basal sample), during (D10, D20, D30, and D40), and after treatment (D55 and D70). Results indicated some hematological and biochemical effects were significantly reduced ( p < 0.05) towards the end of treatment on D40 relative to pre-treatment or baseline values on D0. Post-treatment, all values returned to pre-treatment values within 30 days without any apparent clinical adversities. In conclusion, while these preliminary results are favorable for prolonged use of firocoxib in horses, future studies are required to evaluate the efficacy of prolonged use accompanied with other clinically relevant endpoints in healthy as well as injured or diseased animals. |
