| Autor: |
Lau V; Department of Anatomical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta 55281, Indonesia., Nurkolis F; Department of Biological Sciences, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta 55281, Indonesia., Park MN; Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.; Korean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea., Heriyanto DS; Department of Anatomical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta 55281, Indonesia.; Division of Cardiac, Thoracic, and Vascular Surgery, Department of Surgery, Faculty of Medicine, Public Health, and Nursing/Dr. Sardjito General Hospital, Yogyakarta 55281, Indonesia.; Collaboration Research Center for Precision Oncology Based Omics-PKR PrOmics, Yogyakarta 55281, Indonesia., Taslim NA; Department of Clinical Nutrition, Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia., Tallei TE; Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado 95115, Indonesia., Permatasari HK; Biochemistry and Biomolecular, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia., Tjandrawinata RR; Department of Biotechnology, Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta 12930, Indonesia., Moon S; Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea., Kim B; Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.; Korean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea. |
| Abstrakt: |
The marine environment provides a rich source of distinct creatures containing potentially revolutionary bioactive chemicals. One of these organisms is Caulerpa racemosa , a type of green algae known as green seaweed, seagrapes, or green caviar. This organism stands out because it has great promise for use in medicine, especially in the study of cancer. Through the utilization of computational modeling (in silico) and cellular laboratory experiments (in vitro), the chemical components included in the green seaweed C. racemosa were effectively analyzed, uncovering its capability to treat non-small cell lung cancer (NSCLC). The study specifically emphasized blocking SRC, STAT3, PIK3CA, MAPK1, EGFR, and JAK1 using molecular docking and in vitro. These proteins play a crucial role in the EGFR Tyrosine Kinase Inhibitor Resistance pathway in NSCLC. The chemical Caulersin (C2) included in C. racemosa extract (CRE) has been identified as a potent and effective agent in fighting against non-small cell lung cancer (NSCLC), both in silico and in vitro. CRE and C2 showed a level of inhibition similar to that of osimertinib (positive control/NSCLC drug). |
