Singapore tuberculosis (TB) clinical management guidelines 2024: A modified Delphi adaptation of international guidelines for drug-susceptible TB infection and pulmonary disease.

Autor:	Ang MLT; National Public Health Laboratory, National Centre for Infectious Diseases, Singapore., Chan SM; Division of Paediatric Infectious Diseases, Khoo Teck Puat-National University Children's Medical Institute, National University Hospital, Singapore.; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Cheng LT; Department of Diagnostic Radiology, Singapore General Hospital, Singapore., Cheong HY; Department of Infectious Diseases, Changi General Hospital, Singapore., Chew KL; Department of Laboratory Medicine, National University Hospital, Singapore., Chlebicki PM; Department of Infectious Diseases, Singapore General Hospital, Singapore., Hsu LY; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Kaw GJL; Diagnostic Radiology, Tan Tock Seng Hospital, Singapore., Kee ACL; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Medicine, National University Hospital, Singapore., Ng MCW; SingHealth Polyclinics, Singapore Health Services, Singapore., Ong RTH; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Ong CWM; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Medicine, National University Hospital, Singapore., Quah JL; Department of Respiratory & Critical Care Medicine, Changi General Hospital, Singapore., Selvamani DB; Bukit Panjang Polyclinic, National University Polyclinics, Singapore., Sng LH; Department of Microbiology, Singapore General Hospital, Singapore., Tan JBX; Department of Microbiology, Singapore General Hospital, Singapore., Tan CH; Diagnostic Radiology, Tan Tock Seng Hospital, Singapore., Tay JY; Department of Infectious Diseases, National Centre for Infectious Diseases, Singapore., Teo LLS; Department of Diagnostic Imaging, National University Hospital, Singapore.; Diagnostic Radiology, Yong Loo Lin School of Medicine, Singapore., Thoon KC; Division of Medicine, KK Women's & Children's Hospital, Singapore., Yan GZ; Department of Laboratory Medicine, National University Hospital, Singapore., Chen JI; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Hud BMH; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Khoo BBJ; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Lee DYX; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Ng BXY; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Park JY; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Tan BYT; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Yang Q; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
Jazyk:	angličtina
Zdroj:	Annals of the Academy of Medicine, Singapore [Ann Acad Med Singap] 2024 Mar 27; Vol. 53 (3), pp. 170-186. Date of Electronic Publication: 2024 Mar 27.
DOI:	10.47102/annals-acadmedsg.2023391
Abstrakt:	Introduction: Tuberculosis (TB) remains endemic in Singapore. Singapore's clinical practice guidelines for the management of tuberculosis were first published in 2016. Since then, there have been major new advances in the clinical management of TB, ranging from diagnostics to new drugs and treatment regimens. The National TB Programme convened a multidisciplinary panel to update guidelines for the clinical management of drug-susceptible TB infection and disease in Singapore, contextualising current evidence for local practice. Method: Following the ADAPTE framework, the panel systematically reviewed, scored and synthesised English-language national and international TB clinical guidelines published from 2016, adapting recommendations for a prioritised list of clinical decisions. For questions related to more recent advances, an additional primary literature review was conducted via a targeted search approach. A 2-round modified Delphi process was implemented to achieve consensus for each recommendation, with a final round of edits after consultation with external stakeholders. Results: Recommendations for 25 clinical questions spanning screening, diagnosis, selection of drug regimen, monitoring and follow-up of TB infection and disease were formulated. The availability of results from recent clinical trials led to the inclusion of shorter treatment regimens for TB infection and disease, as well as consensus positions on the role of newer technologies, such as computer-aided detection-artificial intelligence products for radiological screening of TB disease, next-generation sequencing for drug-susceptibility testing, and video observation of treatment. Conclusion: The panel updated recommendations on the management of drug-susceptible TB infection and disease in Singapore.
Databáze:	MEDLINE
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